Reference Report

Reference
Citation	Scholz, H., Ramond, J., Singh, C.M., Heberlein, U. (2000). Functional ethanol tolerance in Drosophila. Neuron 28(1): 261--271. (Export to RIS)
FlyBase ID	FBrf0131396
Publication Type	Research paper
PubMed ID	11086999
PubMed Abstract	In humans, repeated alcohol consumption leads to the development of tolerance, manifested as a reduced physiological and behavioral response to a particular dose of alcohol. Here we show that adult Drosophila develop tolerance to the sedating and motor-impairing effects of ethanol with kinetics of acquisition and dissipation that mimic those seen in mammals. Importantly, this tolerance is not caused by changes in ethanol absorption or metabolism. Rather, the development of tolerance requires the functional and structural integrity of specific central brain regions. Mutants unable to synthesize the catecholamine octopamine are also impaired in their ability to develop tolerance. Taken together, these data show that Drosophila is a suitable model system in which to study the molecular and neuroanatomical bases of ethanol tolerance.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Alleles (20)
	064Ya^064Ya agn¹ ccb² cex^KS181 Ctet\TeTxLC^TNT.Scer\UAS ebo⁶⁷⁸ ebo¹⁰⁴¹ ebo^KS234 Ecol\lacZ^Scer\UAS.cBa mbd¹ mnb¹ nob^KS49 Nrg⁸⁹² Scer\GAL4^007Y Scer\GAL4^064Ya Scer\GAL4^078Y Scer\GAL4^c561 sol¹ Tbh^nM18 vap^KS67
Constructs (2)
	P{UAS-lacZ.B} P{UAS-TeTxLC.tnt}
Genes (15)
	064Ya agn ccb cex Ctet\TeTxLC ebo Ecol\lacZ mbd mnb nob Nrg Scer\GAL4 sol Tbh vap
Insertions (5)
	P{GAL4}064Ya^064Ya P{GAL4}064Yb P{GAL4}dpr8^c561 P{GawB}007Y P{GawB}078Y
Transcripts (4)
	Scer\GAL4^007YRA Scer\GAL4^064YaRA Scer\GAL4^078YRA Scer\GAL4^c561RA