Reference Report

Reference
Citation	Song, Y., Chung, S., Kunes, S. (2000). Combgap relays wingless signal reception to the determination of cortical cell fate in the Drosophila visual system. Mol. Cell 6(5): 1143--1154. (Export to RIS)
FlyBase ID	FBrf0131401
Publication Type	Research paper
PubMed ID	11106753
PubMed Abstract	The dorsoventral axis of the Drosophila visual cortex is patterned by nonautonomous signals expressed at its dorsal and ventral margins. wingless (wg) expression at the margins induces decapentaplegic (dpp), optomotor blind (omb), and aristaless in adjacent domains. We show that Combgap, a zinc finger protein, represses Wg target gene expression in the visual cortex. Wg signal reception downregulates combgap expression and derepresses target gene transcription. Combgap participates in a Hedgehog-controlled circuit in the developing wing and leg by regulating the expression of Cubitus interruptus. Combgap is thus a tissue-specific relay between Wingless and its target genes for the determination of cell fate in the visual cortex.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mol. Cell
Title	Molecular Cell
Publication Year	1997-
ISBN/ISSN	1097-2765 1097-4164
Data from Reference
Alleles (14)
	al⁰⁴³⁵² Axn^A2.Scer\UAS cg¹ cg^k11504 cg^Scer\UAS.cSa cg^unspecified cg^Δ10 Ecol\lacZ^al-04352 Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^wg-17en40cP1 Scer\GAL4^bi-md653 Scer\GAL4^hs.PB Scer\GAL4^{Scer\FRT.Rnor\CD2.αTub84B} Scer\GAL4^unspecified
Constructs (5)
	P{BS3.0} P{GAL4-Hsp70.PB} P{GAL4-αTub84B(FRT.CD2).P} P{UAS-Axn.A2} P{UAS-cg.S}
Genes (9)
	al Axn bi cg ci Dll Ecol\lacZ en Scer\GAL4
Insertions (4)
	P{en1}wg^17en40cP1 P{GawB}bi^md653 P{lacW}cg^k11504 P{PZ}al⁰⁴³⁵²