Reference Report

Reference
Citation	Xu, C., Kauffmann, R.C., Zhang, J., Kladny, S., Carthew, R.W. (2000). Overlapping activators and repressors delimit transcriptional response to receptor tyrosine kinase signals in the Drosophila eye. Cell 103(1): 87--97. (Export to RIS)
FlyBase ID	FBrf0131428
Publication Type	Research paper
PubMed ID	11051550
PubMed Abstract	Regulated transcription of the prospero gene in the Drosophila eye provides a model for how gene expression is specifically controlled by signals from receptor tyrosine kinases. We show that prospero is controlled by signals from the EGF receptor DER and the Sevenless receptor. A direct link is established between DER activation of a transcription enhancer in prospero and binding of two transcription factors that are targets of DER signaling. Binding of the cell-specific Lozenge protein is also required for activation, and overlapping Lozenge protein distribution and DER signaling establishes expression in a subset of equivalent cells competent to respond to Sevenless. We show that Sevenless activates prospero independent of the enhancer and involves targeted degradation of Tramtrack, a transcription repressor.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (34)
	aop^ACT.GMR aop^ACT.sev btl::Egfr^{Scer\UAS.T:λ\cI-DD} Ecol\lacZ^pros.3x2.5 Ecol\lacZ^pros.4x1.2 Ecol\lacZ^{pros.4x1.2-ets} Ecol\lacZ^{pros.4x1.2-lz} Ecol\lacZ^pros.5 Ecol\lacZ^pros.6.8 Ecol\lacZ^pros.6xTTK Ecol\lacZ^pros.7.5 Ecol\lacZ^pros.8.0 Ecol\lacZ^pros.9.1 Ecol\lacZ^pros.12.2 Ecol\lacZ^pros.16 Ecol\lacZ^pros.H3 Ecol\lacZ^pros.IN Ecol\lacZ^pros.M7.2 Ecol\lacZ^pros.PR Ecol\lacZ^pros.Δ1.2 Ecol\lacZ^pros.Δ2.3 Ecol\lacZ^pros.Δ3.3 Egfr::tor^{t4021E.hs.sev} Egfr^DN.Scer\UAS Egfr^tsla lz^L lz^r1 pnt^Δ88 pros^t24.2 Scer\GAL4^hs.2sev Scer\GAL4^lz-gal4 sev¹⁴ T:λ\cI^DD ttk^p88.Scer\UAS
Constructs (27)
	P{GAL4-Hsp70.sev} P{GMR-yan^ACT} P{pros^t24.2} P{pros-lacZ.3x2.5} P{pros-lacZ.4x1.2} P{pros-lacZ.4x1.2-ets} P{pros-lacZ.4x1.2-lz} P{pros-lacZ.5} P{pros-lacZ.6.8} P{pros-lacZ.6xTTK} P{pros-lacZ.7.5} P{pros-lacZ.8.0} P{pros-lacZ.9.1} P{pros-lacZ.12.2} P{pros-lacZ.16} P{pros-lacZ.H3} P{pros-lacZ.IN} P{pros-lacZ.M7.2} P{pros-lacZ.PR} P{pros-lacZ.Δ1.2} P{pros-lacZ.Δ2.3} P{pros-lacZ.Δ3.3} P{sE-torso⁴⁰²¹-DER} P{sev-yan^ACT} P{UAS-Egfr.DN} P{UAS-Egfr.λtop} P{UAS-ttk.p88}
Genes (15)
	aop B Bgb btl::Egfr Dvir\pros Ecol\lacZ Egfr Egfr::tor lz pnt pros Scer\GAL4 sev T:λ\cI ttk
Insertions (1)
	P{GawB}lz^gal4
Sequence features (5)
	pros_6.8 pros_12.2 pros_eye_enhancer pros_H3 pros_Pros5