|Citation||Hedengren, M., Borge, K., Hultmark, D. (2000). Expression and evolution of the Drosophila Attacin/Diptericin gene family. Biochem. Biophys. Res. Commun. 279(2): 574--581. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||We describe the genes for three new glycine-rich antimicrobial peptides in Drosophila, two attacins (AttC and AttD) and one diptericin (DptB). Their structures support the proposal that these glycine-rich antimicrobial peptides evolved from a common ancestor and are probably also related to proline-rich peptides such as drosocin. AttC is similar to the nearby AttA and AttB genes. AttD is more divergent and located on a different chromosome. Intriguingly, AttD may encode an intracellular attacin. DptB is linked in tandem to the closely related Diptericin. However, the DptB gene product contains a furin-like cleavage site and may be processed in an attacin-like fashion. All attacin and diptericin genes are induced after bacterial challenge. This induction is reduced in imd mutants, and unexpectedly also in Tl(-) mutants. The 18w mutation particularly affects the induction of AttC, which may be a useful marker for 18w signaling.|
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|Language of Publication||English|
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|Abbreviation||Biochem. Biophys. Res. Commun.|
|Title||Biochemical and Biophysical Research Communications|
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