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Reference Report
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| Citation | Hedengren, M., Borge, K., Hultmark, D. (2000). Expression and evolution of the Drosophila Attacin/Diptericin gene family. Biochem. Biophys. Res. Commun. 279(2): 574--581. (Export to RIS) | ||
| FlyBase ID | FBrf0132250 | ||
| Publication Type | Research paper | ||
| PubMed ID | 11118328 | ||
| PubMed Abstract | We describe the genes for three new glycine-rich antimicrobial peptides in Drosophila, two attacins (AttC and AttD) and one diptericin (DptB). Their structures support the proposal that these glycine-rich antimicrobial peptides evolved from a common ancestor and are probably also related to proline-rich peptides such as drosocin. AttC is similar to the nearby AttA and AttB genes. AttD is more divergent and located on a different chromosome. Intriguingly, AttD may encode an intracellular attacin. DptB is linked in tandem to the closely related Diptericin. However, the DptB gene product contains a furin-like cleavage site and may be processed in an attacin-like fashion. All attacin and diptericin genes are induced after bacterial challenge. This induction is reduced in imd mutants, and unexpectedly also in Tl(-) mutants. The 18w mutation particularly affects the induction of AttC, which may be a useful marker for 18w signaling. | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Biochem. Biophys. Res. Commun. | ||
| Title | Biochemical and Biophysical Research Communications | ||
| Publication Year | 1959- | ||
| ISBN/ISSN | 0006-291X | ||
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Data from Reference
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| Alleles (7)
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| Genes (15)
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