Reference Report

Reference
Citation	Teleman, A.A., Cohen, S.M. (2000). Dpp gradient formation in the Drosophila wing imaginal disc. Cell 103(6): 971--980. (Export to RIS)
FlyBase ID	FBrf0132263
Publication Type	Research paper
PubMed ID	11136981
PubMed Abstract	The secreted signaling protein Dpp acts as a morphogen to pattern the anterior-posterior axis of the Drosophila wing. Dpp activity is required in all cells of the developing wing imaginal disc, but the ligand gradient that supports this activity has not been characterized. Here we make use of a biologically active form of Dpp tagged with GFP to examine the ligand gradient. Dpp-GFP forms an unstable extracellular gradient that spreads rapidly in the wing disc. The activity gradient visualized by MAD phosphorylation differs in shape from the ligand gradient. The pMAD gradient adjusted to compartment size when this was experimentally altered. These observations suggest that the Dpp activity gradient may be shaped at the level of receptor activation.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (14)
	dpp^d8 dpp^d12 dpp^{MtnA.T:Avic\GFP-EGFP} dpp^{Scer\UAS.T.T:Avic\GFP-EGFP} Ecol\lacZ^dpp.BS3.0 hh^ts2 Hsap\TFRC^Scer\UAS.cSa Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} Pi3K92E^{Scer\UAS.T:Hsap\MYC,T:Hsap\CAAX} Scer\GAL4^Bx-MS1096 Scer\GAL4^dpp.blk1 Scer\GAL4^en-e16E T:Avic\GFP^EGFP w^+mC
Constructs (6)
	P{BS3.0} P{Dp110^D954A} P{Dp110-CAAX} P{GAL4-dpp.blk1} P{UAS-dpp.GFP.T} P{UAS-Hsap\TFRC}
Genes (18)
	brk ci Dll dpp Ecol\lacZ Fas2 hh Hsap\TFRC Mad Pi3K92E salm Scer\GAL4 T:Avic\GFP T:Hsap\CAAX T:Hsap\MYC tkv w wg
Insertions (2)
	P{en2.4-GAL4}e16E P{GawB}Bx^MS1096