Reference Report

Reference
Citation	Nolo, R., Abbott, L.A., Bellen, H.J. (2001). Drosophila Lyra mutations are gain-of-function mutations of senseless. Genetics 157(1): 307--315. (Export to RIS)
FlyBase ID	FBrf0132337
Publication Type	Research paper
PubMed ID	11139511
PubMed Abstract	The Lyra mutation was first described by Jerry Coyne in 1935. Lyra causes recessive pupal lethality and adult heterozygous Lyra mutants exhibit a dominant loss of the anterior and posterior wing margins. Unlike many mutations that cause loss of wing tissue (e.g., scalloped, Beadex, cut, and apterous-Xasta), Lyra wing discs do not exhibit increased necrotic or apoptotic cell death, nor do they show altered BrdU incorporation. However, during wing disc eversion, loss of the anterior and posterior wing margins is apparent. We have previously shown that senseless, a gene that is necessary and sufficient for peripheral nervous system (PNS) development, is allelic to Lyra. Here we show by several genetic criteria that Lyra alleles are neomorphic alleles of senseless that cause ectopic expression of SENSELESS in the wing pouch. Similarly, overexpression of SENSELESS in the wing disc causes loss of wing margin tissue, thereby mimicking the Lyra phenotype. Lyra mutants display aberrant expression of DELTA, VESTIGIAL, WINGLESS, and CUT. As in Lyra mutants, overexpression of SENSELESS in some areas of the wing pouch also leads to loss of WINGLESS and CUT. In summary, our data indicate that overexpression of SENSELESS causes a severe reduction in NOTCH signaling that in turn may lead to decreased transcription of several key genes required for wing development, leading to a failure in cell proliferation and loss of wing margin tissue.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (3)
	Df(3L)Ly Df(3L)S122804 Df(3L)Δ130
Alleles (21)
	Ecol\lacZ^Scer\UAS.cUa Ecol\lacZ^vg.806 Ecol\lacZ^vg.int2.1 l(3)neo19¹ Scer\GAL4^bbg-C96 Scer\GAL4^C1003 Scer\GAL4^dpp.blk1 sens^E1 sens^E2 sens^E53 sens^E54 sens^E58 sens^E64 sens^E69 sens^E87 sens^I235 sens^Ly-1 sens^M256 sens^Scer\UAS.cNa sens^SX67 sens^SX67R12
Constructs (5)
	P{GAL4-dpp.blk1} P{UAS-lacZ.U} P{UAS-sens.N} P{vg(806)-lacZ} P{vg(D/V)-lacZ}
Genes (10)
	ct Dl Ecol\lacZ l(3)neo19 sc Scer\GAL4 sens stg vg wg
Insertions (4)
	P{GawB}bbg^C96 P{GawB}C1003 P{hsneo}l(3)neo19¹ P{lArB}A77.1M3