Reference Report

Reference
Citation	Ohshiro, T., Yagami, T., Zhang, C., Matsuzaki, F. (2000). Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast. Nature 408(6812): 593--596. (Export to RIS)
FlyBase ID	FBrf0132417
Publication Type	Research paper
PubMed ID	11117747
PubMed Abstract	Cellular diversity during development arises in part from asymmetric divisions, which generate two distinct cells by transmitting localized determinants from a progenitor cell into one daughter cell. In Drosophila, neuroblasts undergo typical asymmetric divisions to produce another neuroblast and a ganglion mother cell. At mitosis, neural fate determinants, including Prospero and Numb, localize to the basal cortex, from which the ganglion mother cell buds off; Inscuteable and Bazooka, which regulate spindle orientation, localize apically. Here we show that a tumour-suppressor protein, Lethal giant larvae (Lgl), is essential for asymmetric cortical localization of all basal determinants in mitotic neuroblasts, and is therefore indispensable for neural fate decisions. Lgl, which itself is uniformly cortical, interacts with several types of Myosin to localize the determinants. Another tumour-suppressor protein, Lethal discs large (Dlg), participates in this process by regulating the localization of Lgl. The localization of the apical components is unaffected in lgl or dlg mutants. Thus, Lgl and Dlg act in a common process that differentially mediates cortical protein targeting in mitotic neuroblasts, and that creates intrinsic differences between daughter cells.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Alleles (15)
	dlg1¹⁴ Ecol\lacZ^neur-A101 fzy¹ l(2)gl¹ l(2)gl⁴ l(2)gl^Scer\UAS.cOa l(2)gl^ts3 mira^{Scer\UAS.T:Avic\GFP-S65T.I167T} numb² numb^hs.PU Scer\GAL4^da.G32 Scer\GAL4^pros.PMG T:Avic\GFP^S65T.I167T zip¹ zip^IIX62
Constructs (5)
	P{GAL4-da.G32} P{GAL4-pros.MG} P{hs-numb} P{UAS-l(2)gl.O} P{UAS-miranda-GFP.O}
Genes (14)
	baz dlg1 Ecol\lacZ fzy insc l(2)gl mira numb pon pros raps Scer\GAL4 T:Avic\GFP zip
Insertions (1)
	P{lArB}neur^A101