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Citation
Rajagopalan, S., Nicolas, E., Vivancos, V., Berger, J., Dickson, B.J. (2000). Crossing the midline: roles and regulation of Robo receptors.  Neuron 28(3): 767--777.
FlyBase ID
FBrf0132432
Publication Type
Research paper
Abstract

In the Drosophila CNS, the midline repellent Slit acts at short range through its receptor Robo to control midline crossing. Longitudinal axons express high levels of Robo and avoid the midline; commissural axons that cross the midline express only low levels of Robo. Robo levels are in turn regulated by Comm. Here, we show that the Slit receptors Robo2 and Robo3 ensure the fidelity of this crossing decision: rare crossing errors occur in both robo2 and robo3 single mutants. In addition, low levels of either Robo or Robo2 are required to drive commissural axons through the midline: only in robo,robo2 double mutants do axons linger at the midline as they do in slit mutants. Robo2 and Robo3 levels are also tightly regulated, most likely by a mechanism similar to but distinct from the regulation of Robo by Comm.

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PubMed Central ID
Related Publication(s)
Review

Paper alert.
Jones, 2001, Curr. Opin. Genet. Dev. 11(2): 115 [FBrf0136680]

Note

New roundabouts send axons into the fas lane.
Rusch and Van Vactor, 2000, Neuron 28(3): 637--640 [FBrf0132429]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference
    Alleles (19)
    Gene Groups (1)
    Genes (10)
    Insertions (2)
    Experimental Tools (1)
    Transgenic Constructs (4)