Reference Report

Reference
Citation	Nagel, A.C., Apidianakis, Y., Wech, I., Maier, D., Delidakis, C., Preiss, A. (2000). Neural hyperplasia induced by RNA interference with m4/m gene activity. Mech. Dev. 98(1-2): 19--28. (Export to RIS)
FlyBase ID	FBrf0133204
Publication Type	Research paper
PubMed ID	11044604
PubMed Abstract	The E(spl) complex (E(spl)-C) contains three different classes of genes that are downstream of Notch signaling. The bHLH genes mediate the Notch signal by repressing proneural gene activity, for example during the singularization of mechanosensory organ precursor cells (SOPs). Genes of the second class, the E(spl) m4/malpha family, antagonize this process if overexpressed. Here we show that this is based on dominant-negative effects since RNA interference gives neurogenic phenotypes indistinguishable from E(spl)-C mutations. Furthermore, a third member of the m4/malpha gene family, named bbu/tom, behaves differently with respect to RNA expression patterns, its regulation by Notch signaling and loss of function phenotypes.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Aberrations (7)
	Df(3R)boss15 Df(3R)Espl1 Df(3R)Espl9 Df(3R)P709 Df(3R)Pr4 Df(3R)X10 Tp(3;3)Vno
Alleles (14)
	E(spl)m4-BFM^dsRNA.cNa E(spl)m4-BFM^Scer\UAS.cAa E(spl)mα-BFM^dsRNA.cNa E(spl)mα-BFM^Scer\UAS.cAa Ecol\lacZ^{E(spl).-1166+87} Ecol\lacZ^neur-A101 Ecol\lacZ^scrt-439 N^{int.G.Scer\UAS} Scer\GAL4^bi-omb-Gal4 Scer\GAL4^pnr-MD237 Scer\GAL4^prd.RG1 Su(H)² Tom^dsRNA.cNa Tom^Scer\UAS.cNa
Constructs (6)
	P{GAL4-prd.F} P{m8-lacZ} P{UAS-m4.A} P{UAS-mα.A} P{UAS-N.intra.G} P{UAS-Tom.N}
Genes (12)
	E(spl)m2-BFM E(spl)m3-HLH E(spl)m4-BFM E(spl)m6-BFM E(spl)m7-HLH E(spl)mα-BFM Ecol\lacZ Kaz-m1 N Scer\GAL4 Su(H) Tom
Insertions (4)
	P{GAL4}bi^omb-Gal4 P{GawB}pnr^MD237 P{lacW}439 P{lArB}neur^A101