Reference Report

Reference
Citation	Brogiolo, W., Stocker, H., Ikeya, T., Rintelen, F., Fernandez, R., Hafen, E. (2001). An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr. Biol. 11(4): 213--221. (Export to RIS)
FlyBase ID	FBrf0134520
Publication Type	Research paper
PubMed ID	11250149
PubMed Abstract	Size regulation is fundamental in developing multicellular organisms and occurs through the control of cell number and cell size. Studies in Drosophila have identified an evolutionarily conserved signaling pathway that regulates organismal size and that includes the Drosophila insulin receptor substrate homolog Chico, the lipid kinase PI(3)K (Dp110), DAkt1/dPKB, and dS6K.We demonstrate that varying the activity of the Drosophila insulin receptor homolog (DInr) during development regulates organ size by changing cell size and cell number in a cell-autonomous manner. An amino acid substitution at the corresponding position in the kinase domain of the human and Drosophila insulin receptors causes severe growth retardation. Furthermore, we show that the Drosophila genome contains seven insulin-like genes that are expressed in a highly tissue- and stage-specific pattern. Overexpression of one of these insulin-like genes alters growth control in a DInr-dependent manner.This study shows that the Drosophila insulin receptor autonomously controls cell and organ size, and that overexpression of a gene encoding an insulin-like peptide is sufficient to increase body size.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Curr. Biol.
Title	Current Biology
Publication Year	1991-
ISBN/ISSN	0960-9822
Data from Reference
Aberrations (1)
	Df(3L)AC1
Alleles (14)
	Ilp2^Scer\UAS.cBa InR³¹ InR²¹¹ InR³⁰⁴ InR³³⁹ InR³⁵³ InR^E19 InR^Scer\UAS.cHa InR^unspecified Scer\GAL4^Act5C.PP Scer\GAL4^ey.PH Scer\GAL4^GMR.PB Scer\GAL4^hs.PB Scer\GAL4^Scer\FRT.GMR
Constructs (6)
	P{GAL4-Act5C(-FRT).P} P{GAL4-Hsp70.PB} P{GMR-GAL4.FRT} P{GMR-GAL4(FRT-)} P{UAS-Ilp2.B} P{UAS-InR.H}
Genes (11)
	CG32052 GMR Ilp1 Ilp2 Ilp3 Ilp4 Ilp5 Ilp6 Ilp7 InR Scer\GAL4