Reference Report

Reference
Citation	Scott, E.K., Lee, T., Luo, L. (2001). enok encodes a Drosophila putative histone acetyltransferase required for mushroom body neuroblast proliferation. Curr. Biol. 11(2): 99--104. (Export to RIS)
FlyBase ID	FBrf0134527
Publication Type	Research paper
PubMed ID	11231125
PubMed Abstract	Mushroom bodies in the Drosophila brain are centers for olfactory learning and memory. We have previously shown that the mushroom bodies comprise three types of neurons with distinct axonal projections. These three types of neurons are generated sequentially from common neuroblasts. We report here the identification of a gene that we have named enoki mushroom (enok), which when it is mutated gives rise to mushroom bodies with reduced axonal structures. enok encodes a putative histone acetyltransferase (HAT) of the MYST family, members of which have been implicated as important modulators of transcriptional activity. A single amino acid change in the zinc finger motif of the putative catalytic HAT domain gives the same phenotype as a null allele, and this finding indicates the importance of HAT activity to Enok's function. Further phenotypic analysis demonstrates that the mushroom body defect is due to an arrest in neuroblast proliferation rather than a failure of either cell fate switching or axon branching. Clonal analyses in the wing discs and the ovaries suggest that enok is essential for normal cell proliferation in some, but not all, tissues. Our results provide in vivo evidence for essential functions of a histone acetyltransferase in the construction of the Drosophila brain.
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Supplementary material	enok encodes a Drosophila putative histone acetyltransferase required for mushroom body neuroblast proliferation. [FBrf0135156]
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Curr. Biol.
Title	Current Biology
Publication Year	1991-
ISBN/ISSN	0960-9822
Data from Reference
Aberrations (1)
	Df(2R)gek^D23
Alleles (6)
	enok¹ enok² enok^+tSa gek^D23 Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^ey-OK107
Constructs (2)
	P{enok-rescue-construct} P{UAS-mCD8::GFP.L}
Genes (5)
	enok gek Mmus\Cd8a Scer\GAL4 T:Avic\GFP
Insertions (1)
	P{GawB}ey^OK107