Reference Report

Reference
Citation	Kerber, B., Monge, I., Mueller, M., Mitchell, P.J., Cohen, S.M. (2001). The AP-2 transcription factor is required for joint formation and cell survival in Drosophila leg development. Development 128(8): 1231--1238. (Export to RIS)
FlyBase ID	FBrf0134566
Publication Type	Research paper
PubMed ID	11262225
PubMed Abstract	Flies mutant for the Drosophila homologue of the mammalian transcription factor AP-2 show a severe reduction in leg length and fail to develop joint structures. Presumptive joint cells express dAP-2 in response to Notch signaling. dAP-2 is required for joint cell differentiation and can induce formation of supernumerary joints when misexpressed. Although dAP-2 is expressed only in presumptive joint cells, its activity is required to support cell survival in the entire leg segment. Taken together, our data indicate that dAP-2 is an important mediator of Notch activity in leg development.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(3L)croc-2
Alleles (13)
	Ecol\lacZ^bib-6E1 N^{intra.GS.Scer\UAS} N^l1N-ts1 Rnor\CD2^HLHmβ.PdC Scer\GAL4^dpp.blk1 Scer\GAL4^ptc-559.1 Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C} Su(H)⁸ TfAP-2² TfAP-2¹⁵ TfAP-2^Scer\UAS.cMa TfAP-2^stummelbein TfAP-2^unspecified
Constructs (5)
	P{GAL4-Act5C(FRT.CD2).P} P{GAL4-dpp.blk1} P{HLHmβ-CD2.dC} P{UAS-AP-2.M} P{UAS-N.intra.GS}
Genes (12)
	bib croc dac Dll E(spl)m8-HLH Ecol\lacZ hth N Rnor\CD2 Scer\GAL4 Su(H) TfAP-2
Insertions (3)
	P{GawB}ptc^559.1 P{lacZ}6E1 P{Mcp-w#14}TfAP-2^stummelbein