Reference Report

Reference
Citation	Treisman, J.E. (2001). Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development. Development 128(4): 603--615. (Export to RIS)
FlyBase ID	FBrf0134573
Publication Type	Research paper
PubMed ID	11171343
PubMed Abstract	We have identified mutations in two genes, blind spot and kohtalo, that encode Drosophila homologues of human TRAP240 and TRAP230, components of a large transcriptional coactivation complex homologous to the yeast Mediator complex. Loss of either blind spot or kohtalo has identical effects on the development of the eye-antennal disc. Eye disc cells mutant for either gene can express decapentaplegic and atonal in response to Hedgehog signaling, but they maintain inappropriate expression of these genes and fail to differentiate further. Mutant cells in the antennal disc lose expression of Distal-less and misexpress eyeless, suggesting a partial transformation towards the eye fate. blind spot and kohtalo are not required for cell proliferation or survival, and their absence cannot be rescued by activation of the Hedgehog or Notch signaling pathways. These novel and specific phenotypes suggest that TRAP240 and TRAP230 act in concert to mediate an unknown developmental signal or a combination of signals.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(3L)kto2
Alleles (18)
	Avic\GFP^Ubi-p63E.PD ci^{m1-4.Scer\UAS.T:Ivir\HA1} Dl::N^{ΔECN.Scer\UAS} Ecol\lacZ^arm.PV Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^wg-en11 hh^Scer\UAS.cAa kto¹ kto^T241 kto^T555 kto^T631 Scer\FLP1^ey.PB Scer\GAL4^ey.PH skd^L7062 skd^rK760 skd^T13 skd^T413 skd^T606
Constructs (8)
	P{arm-lacZ.V} P{BS3.0} P{ey-FLP.B} P{GAL4-ey.H} P{UAS-ci.HA.m1-4} P{UAS-Dl::N.ΔECN} P{UAS-hh.A} P{Ubi-GFP.D}
Genes (16)
	ato Avic\GFP ci dac Dl::N dpp Ecol\lacZ elav ey H hh kto Scer\FLP1 Scer\GAL4 skd T:Ivir\HA1
Insertions (3)
	P{en1}wg^en11 P{lacW}skd^L7062 P{PZ}skd^rK760