Reference Report

Reference
Citation	Pichaud, F., Desplan, C. (2001). A new visualization approach for identifying mutations that affect differentiation and organization of the Drosophila ommatidia. Development 128(6): 815--826. (Export to RIS)
FlyBase ID	FBrf0134582
Publication Type	Research paper
PubMed ID	11222137
PubMed Abstract	The Drosophila eye is widely used as a model system to study neuronal differentiation, survival and axon projection. Photoreceptor differentiation starts with the specification of a founder cell R8, which sequentially recruits other photoreceptor neurons to the ommatidium. The eight photoreceptors that compose each ommatidium exist in two chiral forms organized along two axes of symmetry and this pattern represents a paradigm to study tissue polarity. We have developed a method of fluoroscopy to visualize the different types of photoreceptors and the organization of the ommatidia in living animals. This allowed us to perform an F(1) genetic screen to isolate mutants affecting photoreceptor differentiation, survival or planar polarity. We illustrate the power of this detection system using known genetic backgrounds and new mutations that affect ommatidial differentiation, morphology or chirality.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(3L)iro-DFM3
Alleles (24)
	ara^DFM3 Avic\GFP^E.ninaE Avic\GFP^E.Rh4 Avic\GFP^E.Rh5 Avic\GFP^E.Rh6 crb^M82-4 fz^hs.sev M80-11^M80-11 M80-39^M80-39 M80-A32^M80-A32 M80-A33^M80-A33 M82-19^M82-19 M82-19^M82-37 mirr^DFM3 N^act.sev ninaE^{Scer\UAS.T:Avic\GFP-EGFP} Rh3^{Scer\UAS.T:Avic\GFP-EGFP} Rh3^{T:Avic\GFP-EGFP} Rh4^{Scer\UAS.T:Avic\GFP-EGFP} Rh5^{Scer\UAS.T:Avic\GFP-EGFP} Rh6^{Scer\UAS.T:Avic\GFP-EGFP} Scer\GAL4^Rh5.PT T:Avic\GFP^EGFP w^+mC
Constructs (14)
	P{ninaE-EGFP.P} P{Rh3-EGFP.P} P{Rh3-Rh3-EGFP.P} P{Rh4-EGFP.P} P{Rh5-EGFP.P} P{Rh5-GAL4} P{Rh6-EGFP.P} P{sev-fz.T} P{sev-N^act} P{UAS-ninaE-EGFP} P{UAS-Rh3-EGFP} P{UAS-Rh4-EGFP} P{UAS-Rh5-EGFP} P{UAS-Rh6-EGFP}
Genes (19)
	ara Avic\GFP crb fz M80-11 M80-39 M80-A32 M80-A33 M82-19 mirr N ninaE Rh3 Rh4 Rh5 Rh6 Scer\GAL4 T:Avic\GFP w
Sequence features (1)
	ninaE_minimal_promoter