Reference Report

Reference
Citation	Starz-Gaiano, M., Cho, N.K., Forbes, A., Lehmann, R. (2001). Spatially restricted activity of a Drosophila lipid phosphatase guides migrating germ cells. Development 128(6): 983--991. (Export to RIS)
FlyBase ID	FBrf0134584
Publication Type	Research paper
PubMed ID	11222152
PubMed Abstract	Temporal and spatial controls of cell migration are crucial during normal development and in disease. Our understanding, though, of the mechanisms that guide cells along a specific migratory path remains largely unclear. We have identified wunen 2 as a repellant for migrating primordial germ cells. We show that wunen 2 maps next to and acts redundantly with the previously characterized gene wunen, and that known wunen mutants affect both transcripts. Both genes encode Drosophila homologs of mammalian phosphatidic acid phosphatase. Our work demonstrates that the catalytic residues of Wunen 2 are necessary for its repellant effect and that it can affect germ cell survival. We propose that spatially restricted phospholipid hydrolysis creates a gradient of signal necessary and specific for the migration and survival of germ cells.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (5)
	Ab(2;?)wun^CE Df(2R)NYX-D15 Df(2R)w73-1 Df(2R)w73-2 Df(2R)wun-GL
Alleles (19)
	faf^{392.T:Ecol\lacZ} Scer\GAL4^48Y Scer\GAL4^btl.PS Scer\GAL4^elav-C155 Scer\GAL4^h-1J3 Scer\GAL4^how-24B Scer\GAL4^{nos.UTR.T:Hsim\VP16} Scer\GAL4^twi.PG w^+mC wun2^EP2217 wun2^EP2527 wun2^EP2650 wun2^{H274K.Scer\UAS.T:Hsap\MYC} wun2^{H326K.Scer\UAS.T:Hsap\MYC} wun2^{Scer\UAS.T:Hsap\MYC} wun2^{Y225W.Scer\UAS.T:Hsap\MYC} wun^CE wun^EP2607 wun^Scer\UAS.cZa
Constructs (9)
	P{faf-lacZ.F} P{GAL4::VP16-nos.UTR} P{GAL4-btl.S} P{GAL4-twi.G} P{UAS-wun2.H274K} P{UAS-wun2.H326K} P{UAS-wun2.Myc} P{UAS-wun2.Y225W} P{UAS-wun.Z}
Genes (14)
	arm eya faf Mef2 nos Scer\GAL4 T:Ecol\lacZ T:Hsap\MYC T:Hsim\VP16 vas w wun wun2 α-Spec
Insertions (9)
	P{EP}wun2^EP2217 P{EP}wun2^EP2527 P{EP}wun2^EP2650 P{EP}wun^EP2607 P{GawB}48Y P{GawB}elav^C155 P{GawB}h^1J3 P{GawB}how^24B P{hs-hid}Y