Reference Report

Reference
Citation	Apionishev, S., Malhotra, D., Raghavachari, S., Tanda, S., Rasooly, R.S. (2001). The Drosophila UBC9 homologue lesswright mediates the disjunction of homologues in meiosis I. Genes Cells 6(3): 215--224. (Export to RIS)
FlyBase ID	FBrf0134637
Publication Type	Research paper
PubMed ID	11260265
PubMed Abstract	In Saccharomyces cerevisiae and other organisms, the UBC9 (ubiquitin-conjugating 9) protein modifies the function of many different target proteins through covalent attachment of the ubiquitin-like protein SMT-3/SUMO.Using a second-site suppression screen of a mutation in the nod locus with a variable meiotic phenotype, we have identified mutations in the Drosophila melanogaster UBC9 homologue, encoded by the gene lesswright (lwr). lwr mutations dominantly suppress the nondisjunction and cytological defects of female meiotic mutations that affect spindle formation. The lwr lethal phenotype is rescued by a Drosophila UBC9/lwr transgene.We suggest that LWR mediates the dissociation of heterochromatic regions of homologues at the end of meiotic prophase I. Our model proposes that when there is less LWR protein, homologues remain together longer, allowing for more normal spindle formation in mutant backgrounds and therefore more accurate meiotic chromosome segregation.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genes Cells
Title	Genes to cells : devoted to molecular & cellular mechanisms
Publication Year	1996-
ISBN/ISSN	1356-9597
Data from Reference
Aberrations (1)
	Df(2L)lwr¹⁴
Alleles (19)
	Axs^D lwr^4-3 lwr⁵ lwr¹⁴ lwr⁰²⁸⁵⁸ lwr⁰⁵⁴⁸⁶ lwr^Scer\UAS.cAa lwr^semi710 mei-218¹ mei-218⁶ ncd¹ ncd^D nod² nod^a nod^DTW Scer\GAL4^e22c Scer\GAL4^nos.PG Spp¹⁴ w^+mC
Constructs (2)
	P{GAL4-nos.NGT} P{UAS-lwr.A}
Genes (8)
	Axs lwr mei-218 ncd nod Scer\GAL4 Spp w
Insertions (6)
	P{?PZ}lwr^4-3 P{en2.4-GAL4}e22c P{GAL4-nos.NGT}40 P{PZ}lwr⁰²⁸⁵⁸ P{PZ}lwr⁰⁵⁴⁸⁶ P{PZ}lwr^semi710