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Johnson, E., Ringo, J., Dowse, H. (2001). Dynamin, encoded by shibire, is central to cardiac function.  J. exp. Zool. 289(2): 81--89.
FlyBase ID
FBrf0134732
Publication Type
Research paper
Abstract

Employing the Drosophila heart, a model system for genetic and molecular investigation of cardiac physiology, we demonstrate here an essential role for the protein dynamin, encoded by the Drosophila gene shibire(ts) (shi(ts)), in maintaining normal heart function. In flies bearing two temperature-sensitive alleles of shi, shi(ts1) and shi(ts2), heartbeat is both slower and less rhythmic than in wild-type animals. Serotonin and norepinephrine, normally cardioacceleratory in wild type, are without effect in flies bearing the shi mutation. Electrocardiogram (EKG) analysis reveals a bigeminal beat in mutant hearts, unlike the single electrical pulse in wild-type. The gene no action potential (temperature sensitive), with previously-described cardiac aberrations similar to those of shi, interacts with shi: shi/shi;nap/nap mutants have almost wild-type heart function. J. Exp. Zool. 289:81-89 , 2001.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. exp. Zool.
    Title
    Journal of Experimental Zoology
    Publication Year
    1904-2002
    ISBN/ISSN
    0022-104X
    Data From Reference
    Aberrations (2)
    Alleles (3)
    Genes (2)