Reference Report

Reference
Citation	Verheyen, E.M., Mirkovic, I., MacLean, S.J., Langmann, C., Andrews, B.C., MacKinnon, C. (2001). The tissue polarity gene nemo carries out multiple roles in patterning during Drosophila development. Mech. Dev. 101(1-2): 119--132. (Export to RIS)
FlyBase ID	FBrf0134745
Publication Type	Research paper
PubMed ID	11231065
PubMed Abstract	Drosophila nemo was first identified as a gene required for tissue polarity during ommatidial development. We have extended the analysis of nemo and found that it participates in multiple developmental processes. It is required during wing development for wing shape and vein patterning. We observe genetic interactions between nemo and mutations in the Notch, Wingless, Frizzled and Decapentaplegic pathways. Our data support the findings from other organisms that Nemo proteins act as negative regulators of Wingless signaling. nemo mutations cause polarity defects in the adult wing and overexpression of nemo leads to abdominal polarity defects. The expression of nemo during embryogenesis is dynamic and dsRNA inhibition and ectopic expression studies indicate that nemo is essential during embryogenesis.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Aberrations (1)
	Df(3L)pbl-NR
Alleles (24)
	arm^{S10.Scer\UAS.T:Hsap\MYC} bs¹³⁴⁸ Dl^9M Dl^Scer\UAS.cDa dpp^s1 E(spl)mβ-HLH^{Scer\UAS.cdCa} Egfr^dsRNA.cVa H¹ net¹ nmo^adk1 nmo^adk2 nmo^{c4-2.Scer\UAS} nmo^{c5-1.Scer\UAS} nmo^{dsRNA.197-669} nmo^P1 nmo^unspecified pan^Scer\UAS.cWa pan^ΔN.Scer\UAS px¹ Scer\GAL4^32B Scer\GAL4^69B Scer\GAL4^bs-1348 Scer\GAL4^vg.int2.1 w^+mC
Constructs (8)
	P{UAS-arm.S10} P{UAS-Dl.D} P{UAS-E(spl)mβ} P{UAS-nmo.c4-2} P{UAS-nmo.c5-1} P{UAS-pan.dTCF} P{UAS-pan.dTCFΔN} P{vg(int2.1)-GAL4}
Genes (16)
	arm bs Dl dpp E(spl)mβ-HLH Egfr en H net nmo pan px rho Scer\GAL4 T:Hsap\MYC w
Insertions (3)
	P{GAL4}bs¹³⁴⁸ P{GawB}32B P{GawB}69B