Reference Report

Reference
Citation	Schulze, S., Sinclair, D.A., Silva, E., Fitzpatrick, K.A., Singh, M., Lloyd, V.K., Morin, K.A., Kim, J., Holm, D.G., Kennison, J.A., Honda, B.M. (2001). Essential genes in proximal 3L heterochromatin of Drosophila melanogaster. Mol. Gen. Genet. 264(6): 782--789. (Export to RIS)
FlyBase ID	FBrf0134775
Publication Type	Research paper
External Crossreferences
PubMed ID	11254125
PubMed Abstract	We have further characterized essential loci within the centric heterochromatin of the left arm of chromosome 3 (3L) of Drosophila melanogaster, using EMS, radiation and P element mutagenesis. We failed to find any new essential genes, a result that suggests a lower-than-average gene density in this region. Mutations affecting expression of the most proximal gene [lethal 1, l1 or l(3)80Fj] act as dominant suppressors of Polycomb (Pc), behavior which is consistent with a putative trithorax group (trx-G) gene. The third gene to the left of the centromere [lethal 3, l3 or l(3)80Fh] is likely to correspond to verthandi (vtd), a known trx-G gene that plays a role in the regulation of hedgehog (hh) expression and signalling. The intervening gene [lethal 2, l2 or l(3)80Fi] is required throughout development, and mutant alleles have interesting phenotypes; in various allelic combinations that survive, we observe fertility, bristle, wing, eye and cuticle defects.
BIOSIS ID	2001.219765
Zoological Record ID
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Secondary IDs
Language of Publication	English
Additional Languages of Abstract
ISBN
Parent Publication
Publication Type	Journal
Abbreviation	Mol. Gen. Genet.
Title	Molecular and General Genetics
Editors
Publication Year	1967-2001
ISBN/ISSN	0026-8925
Data from Reference
Aberrations (23)
	Df(3L)1-16 Df(3L)1-166 Df(3L)2-66 Df(3L)3-52 Df(3L)6B-29+Df(3R)6B-29 Df(3L)9-56 Df(3L)99 Df(3L)C-2 Df(3L)G-1 Df(3L)K-2 Df(3L)O-1 Df(3L)vtd² Df(3L)vtd³ Df(3L)vtd⁶ Df(3L)vtd⁷ Df(3L)vtd⁸ Df(3L)vtd¹⁰ Df(3L)vtd¹¹ Df(3L)vtd¹² Df(3L)γ-26 Df(3L)γ-28 Df(3L)γ-29 In(3L)vtd⁹
Alleles (30)
	hh^Mrt l(3)80Fe^BH-4 l(3)80Fj^2-30 Pc⁴ RpL15³ RpL15^7-1 RpL15^8-1 RpL15⁷² RpL15^PΔ2 RpL15^PΔ8 vtd² vtd^3-1 vtd³ vtd⁴ vtd^5-1 vtd^5-2 vtd^5-3 vtd⁶ vtd⁷ vtd⁸ vtd⁹ vtd¹⁰ vtd¹¹ vtd¹² vtd^80Fh-1 vtd^80Fh-2 vtd^80Fh-5 vtd^80Fh-6 vtd^80Fh-35 vtd^80Fh-36
Genes (13)
	hh l(3)80Fa l(3)80Fb l(3)80Fc l(3)80Fd l(3)80Fe l(3)80Ff l(3)80Fg l(3)80Fj l(3)81Fa Pc RpL15 vtd
Insertions (8)
	P{}RpL15^7-1 P{}RpL15^8-1 P{}RpL15^PΔ2 P{}RpL15^PΔ8 P{}vtd^3-1 P{}vtd^5-1 P{}vtd^5-2 P{}vtd^5-3