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| Citation | Rutschmann, S., Jung, A.C., Zhou, R., Silverman, N., Hoffmann, J.A., Ferrandon, D. (2000). Role of Drosophila IKK in a Toll-independent antibacterial immune response. Nat. Immunol. 1(4): 342--347. (Export to RIS) | ||
| FlyBase ID | FBrf0134801 | ||
| Publication Type | Research paper | ||
| PubMed ID | 11017107 | ||
| PubMed Abstract | We have generated, by ethylmethane sulfonate mutagenesis, loss-of-function mutants in the Drosophila homolog of the mammalian I-kappa B kinase (IKK) complex component IKK gamma (also called NEMO). Our data show that Drosophila IKK gamma is required for the Relish-dependent immune induction of the genes encoding antibacterial peptides and for resistance to infections by Escherichia coli. However, it is not required for the Toll-DIF-dependent antifungal host defense. The results indicate distinct control mechanisms of the Rel-like transactivators DIF and Relish in the Drosophila innate immune response and show that Drosophila Toll does not signal through a IKK gamma-dependent signaling complex. Thus, in contrast to the vertebrate inflammatory response, IKK gamma is required for the activation of only one immune signaling pathway in Drosophila. | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Nat. Immunol. | ||
| Title | Nature Immunology | ||
| Publication Year | 2000- | ||
| ISBN/ISSN | 1529-2908 1529-2916 | ||
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Data from Reference
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| Aberrations (1)
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| Alleles (16)
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| Genes (18)
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