|Citation||Rutschmann, S., Jung, A.C., Zhou, R., Silverman, N., Hoffmann, J.A., Ferrandon, D. (2000). Role of Drosophila IKK in a Toll-independent antibacterial immune response. Nat. Immunol. 1(4): 342--347. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||We have generated, by ethylmethane sulfonate mutagenesis, loss-of-function mutants in the Drosophila homolog of the mammalian I-kappa B kinase (IKK) complex component IKK gamma (also called NEMO). Our data show that Drosophila IKK gamma is required for the Relish-dependent immune induction of the genes encoding antibacterial peptides and for resistance to infections by Escherichia coli. However, it is not required for the Toll-DIF-dependent antifungal host defense. The results indicate distinct control mechanisms of the Rel-like transactivators DIF and Relish in the Drosophila innate immune response and show that Drosophila Toll does not signal through a IKK gamma-dependent signaling complex. Thus, in contrast to the vertebrate inflammatory response, IKK gamma is required for the activation of only one immune signaling pathway in Drosophila.|
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|Language of Publication||English|
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