Subject: Helping FlyBase: ADRC-10464, 10527, 10916
Dear Douglas,
We are currently curating the abstracts for the upcoming 42nd
(Washington, D.C.) Annual Drosophila Research Conference, for FlyBase.
I am writing in connection with your abstracts:
'Knock your SOCS off: Regulation of the JAK/STAT Pathway.'
'SOCS36E: a negative regulator of the JAK/STAT pathway in Drosophila
melanogaster.'
'Biochemical interactions between the regulatory factors of the JAK/STAT
pathway.'
You mention three Socs genes, Socs36E, Socs16E and Socs44E. Do you
know which of the Genome Project CG annotations your genes correspond
to? All the CGs have corresponding gene records in FlyBase already and
we don't like to make duplicate records for what is actually the same
gene unless we can't avoid it. If any of your genes does not correspond
to a CG then perhaps you could tell me its map location, as this is
valuable information for the genome annotation project.
Also, we already have a gene record for something called Socs,
published by you in last year's abstracts, which maps to clone
DS04489. Does this correspond to Socs36E, or one of the others?
Thank you for your help,
with best wishes,
Rachel.
Subject: Re: Helping FlyBase: ADRC-10464, 10527, 10916
Hi Rachel,
Each of the Socs genes referenced in the abstracts does correspond
to a CG record, although our cDNA and EST clones appear to have some
differences from the predicted gene structure (but we will provide more on
that over the next few months as we complete sequencing). Below are the
relationships of the predicted Socs genes to the predicted CG gene
records. As you surmised, our reference to Socs from last year's abstract
refers to Socs36E. If you have further questions, feel free to let me
know. We will provide you with updated information about gene structure as
we confirm it.
Socs36E = CG15154 \+ some additional sequence that encodes a Socs box
Socs16D = CG8146 \+ Socs box sequence
Socs44A = CG2160
Doug