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Citation
Tapon, N., Ito, N., Dickson, B.J., Treisman, J.E., Hariharan, I.K. (2001). The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.  Cell 105(3): 345--355.
FlyBase ID
FBrf0135684
Publication Type
Research paper
Abstract

The inherited human disease tuberous sclerosis, characterized by hamartomatous tumors, results from mutations in either TSC1 or TSC2. We have characterized mutations in the Drosophila Tsc1 and Tsc2/gigas genes. Inactivating mutations in either gene cause an identical phenotype characterized by enhanced growth and increased cell size with no change in ploidy. Overall, mutant cells spend less time in G1. Coexpression of both Tsc1 and Tsc2 restricts tissue growth and reduces cell size and cell proliferation. This phenotype is modulated by manipulations in cyclin levels. In postmitotic mutant cells, levels of Cyclin E and Cyclin A are elevated. This correlates with a tendency for these cells to reenter the cell cycle inappropriately as is observed in the human lesions.

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Related Publication(s)
Note

Insulin signaling: lessons from the Drosophila tuberous sclerosis complex, a tumor suppressor.
Montagne et al., 2001, Sci. STKE 2001(105): PE36 [FBrf0139801]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference