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Citation
Sink, H., Rehm, E.J., Richstone, L., Bulls, Y.M., Goodman, C.S. (2001). sidestep encodes a target-derived attractant essential for motor axon guidance in Drosophila.  Cell 105(1): 57--67.
FlyBase ID
FBrf0135687
Publication Type
Research paper
Abstract

At specific choice points in the periphery, subsets of motor axons defasciculate from other axons in the motor nerves and steer into their muscle target regions. Using a large-scale genetic screen in Drosophila, we identified the sidestep (side) gene as essential for motor axons to leave the motor nerves and enter their muscle targets. side encodes a target-derived transmembrane protein (Side) that is a novel member of the immunoglobulin superfamily (IgSF). Side is expressed on embryonic muscles during the period when motor axons leave their nerves and extend onto these muscles. In side mutant embryos, motor axons fail to extend onto muscles and instead continue to extend along their motor nerves. Ectopic expression of Side results in extensive and prolonged motor axon contact with inappropriate tissues expressing Side.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Aberrations (2)
    Alleles (16)
    Genes (6)
    Insertions (5)
    Experimental Tools (1)
    Transgenic Constructs (4)
    Transcripts (4)