Reference Report

Reference
Citation	Halfar, K., Rommel, C., Stocker, H., Hafen, E. (2001). Ras controls growth, survival and differentiation in the Drosophila eye by different thresholds of MAP kinase activity. Development 128(9): 1687--1696. (Export to RIS)
FlyBase ID	FBrf0135730
Publication Type	Research paper
PubMed ID	11290305
PubMed Abstract	Ras mediates a plethora of cellular functions during development. In the developing eye of Drosophila, Ras performs three temporally separate functions. In dividing cells, it is required for growth but is not essential for cell cycle progression. In postmitotic cells, it promotes survival and subsequent differentiation of ommatidial cells. In the present paper, we have analyzed the different roles of Ras during eye development by using molecularly defined complete and partial loss-of-function mutations of Ras. We show that the three different functions of Ras are mediated by distinct thresholds of MAPK activity. Low MAPK activity prolongs cell survival and permits differentiation of R8 photoreceptor cells while high or persistent MAPK activity is sufficient to precociously induce R1-R7 photoreceptor differentiation in dividing cells.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Alleles (25)
	Avic\GFP^{S65T.Scer\UAS.T:SV40\nls2} Ecol\lacZ^arm.PV phl::tor^Y9.Scer\UAS Pi3K92E^2H1 Pi3K92E^A Ras85D⁰⁵⁷⁰³ Ras85D^+t3.6 Ras85D^D38E Ras85D^{G12V.D38E.Scer\UAS} Ras85D^{G12V.D38E.sev} Ras85D^{G12V.Scer\UAS} Ras85D^G12V.sev Ras85D^{G12V.T35S.sev} Ras85D^{G12V.Y40C.Scer\UAS} Ras85D^{G12V.Y40C.sev} Ras85D^x7b Ras85D^Y40C rl^Sem Rlb1^Δ.H Scer\GAL4^Act5C.PP Scer\GAL4^GMR.PF Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C} w^+* w^+mC y^+t*
Constructs (16)
	P{arm-lacZ.V} P{GAL4-Act5C(FRT.CD2).P} P{GAL4-Act5C(-FRT).P} P{GAL4-ninaE.GMR} P{Ras85D^+t3.6} P{Ras85D^D38E} P{Ras85D^Y40C} P{sev-Ras85D.G12V.D38E} P{sev-Ras85D.G12V.T35S} P{sev-Ras85D.G12V.Y40C} P{sev-Ras85D.G12V} P{UAS-GFP^S65T.nls} P{UAS-Raf^torY9} P{UAS-Ras85D.G12V.D38E} P{UAS-Ras85D.G12V.Y40C} P{UAS-Ras85D.G12V}
Genes (13)
	Avic\GFP boss Ecol\lacZ elav phl::tor Pi3K92E Ras85D rl Rlb1 Scer\GAL4 T:SV40\nls2 w y
Insertions (12)
	P{Ras85D^+t3.6}3 P{Ras85D^D38E}27 P{Ras85D^D38E}29 P{Ras85D^Y40C}23 P{Ras85D^Y40C}30 P{sev-Ras85D.G12V.D38E}2 P{sev-Ras85D.G12V.T35S}2 P{sev-Ras85D.G12V.Y40C}1 P{sev-Ras85D.G12V}1 P{UAS-Ras85D.G12V.D38E}3 P{UAS-Ras85D.G12V.Y40C}2 P{UAS-Ras85D.G12V}2