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Citation
Hiller, M.A., Lin, T.Y., Wood, C., Fuller, M.T. (2001). Developmental regulation of transcription by a tissue-specific TAF homolog.  Genes Dev. 15(8): 1021--1030.
FlyBase ID
FBrf0135773
Publication Type
Research paper
Abstract

Alternate forms of the general transcription machinery have been described in several tissues or cell types. However, the role of tissue-specific TBP-associated factors (TAF(II)s) and other tissue-specific transcription components in regulating differential gene expression during development was not clear. Here we show that the cannonball gene of Drosophila encodes a cell type-specific homolog of a more ubiquitously expressed component of the general transcription factor TFIID. cannonball is required in vivo for high level transcription of a set of stage- and tissue-specific target genes during male gametogenesis. Regulation of transcription by cannonball is absolutely required for spermatogenesis, as null mutations block meiotic cell cycle progression and result in a complete failure of spermatid differentiation. Our results demonstrate that cell type-specific TAF(II)s play an important role in developmental regulation of gene expression.

PubMed ID
PubMed Central ID
PMC312677 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference
    Alleles (18)
    Genes (9)
    Insertions (3)
    Experimental Tools (1)
    Transgenic Constructs (2)