Reference Report

Reference
Citation	Axelrod, J.D. (2001). Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling. Genes Dev. 15(10): 1182--1187. (Export to RIS)
FlyBase ID	FBrf0135774
Publication Type	Research paper
PubMed ID	11358862
PubMed Abstract	Drosophila epithelia acquire a planar cell polarity (PCP) orthogonal to their apical-basal axes. Frizzled (Fz) is the receptor for the PCP signal, and Dishevelled (Dsh) transduces the signal. Here, I demonstrate that unipolar relocalization of Dsh to the membrane is required to mediate PCP, but not Wingless (Wg) signaling. Dsh membrane localization reflects the activation of Fz/PCP signaling, revealing that the initially symmetric signal evolves to one that displays unipolar asymmetry, specifying the cells' ultimate polarity. This transition from symmetric to asymmetric Dsh localization requires Dsh function, and reflects an amplification process that generates a steep intracellular activity gradient necessary to determine PCP.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Alleles (20)
	Avic\GFP^Scer\UAS.cUa dsh^{1.T:Avic\GFP-EGFP} dsh¹ dsh³ dsh^{T:Avic\GFP-EGFP} dsh^{ΔbPDZ.Scer\UAS} dsh^{ΔDEP+.Scer\UAS} Ecol\lacZ^Scer\UAS.cUa fz¹⁹ fz²³ fz^Scer\UAS.cAa nkd^{Scer\UAS.T:Hsap\MYC} Scer\GAL4^dpp.blk1 Scer\GAL4^en-e16E Scer\GAL4^insc-Mz1407 Scer\GAL4^ptc-559.1 stan^E45 stan^E59 stan^Scer\UAS.cUa T:Avic\GFP^EGFP
Constructs (10)
	P{dsh.EGFP} P{dsh¹.EGFP} P{GAL4-dpp.blk1} P{UAS-dsh.ΔbPDZ} P{UAS-dsh.ΔDEP+} P{UAS-fmi.U} P{UAS-fz.A} P{UAS-GFP.U} P{UAS-lacZ.U} P{UAS-nkd.myc}
Genes (8)
	Avic\GFP dsh Ecol\lacZ fz nkd Scer\GAL4 stan T:Avic\GFP
Insertions (5)
	P{dsh.EGFP}II P{dsh¹.EGFP}II P{en2.4-GAL4}e16E P{GawB}insc^Mz1407 P{GawB}ptc^559.1