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Citation
Sinclair, D.A.R., Schulze, S., Silva, E., Fitzpatrick, K.A., Honda, B.M. (2000). Essential genes in autosomal heterochromatin of Drosophila melanogaster.  Genetica 109(1-2): 9--18.
FlyBase ID
FBrf0135800
Publication Type
Research paper
Abstract

We are taking two approaches to understanding the structure, function and regulation of essential genes within Drosophila heterochromatin. In the first, we have undertaken a genetic and molecular characterization of essential genes within proximal 3L heterochromatin. The expression of such 'resident' genes within a heterochromatic environment is paradoxical and poorly understood, given that the same environment can inactivate euchromatic sequences (position effect variegation, or PEV). A second approach involves the study of the local chromosomal environment of heterochromatic (het) genes, as assayed both biochemically, and via the effects of genetic modifiers of PEV, the latter being putative components important for het gene expression. Our results to date suggest that the three most proximal genes in 3L heterochromatin have key roles in development, and indicate strong effects of combinations of genetic modifiers of PEV on het gene expression.

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    Language of Publication
    English
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    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetica
    Title
    Genetica
    Publication Year
    1919-
    ISBN/ISSN
    0016-6707
    Data From Reference