Reference Report

Reference
Citation	Sinclair, D.A.R., Schulze, S., Silva, E., Fitzpatrick, K.A., Honda, B.M. (2000). Essential genes in autosomal heterochromatin of Drosophila melanogaster. Genetica 109(1-2): 9--18. (Export to RIS)
FlyBase ID	FBrf0135800
Publication Type	Research paper
External Crossreferences
PubMed ID	11293800
PubMed Abstract	We are taking two approaches to understanding the structure, function and regulation of essential genes within Drosophila heterochromatin. In the first, we have undertaken a genetic and molecular characterization of essential genes within proximal 3L heterochromatin. The expression of such 'resident' genes within a heterochromatic environment is paradoxical and poorly understood, given that the same environment can inactivate euchromatic sequences (position effect variegation, or PEV). A second approach involves the study of the local chromosomal environment of heterochromatic (het) genes, as assayed both biochemically, and via the effects of genetic modifiers of PEV, the latter being putative components important for het gene expression. Our results to date suggest that the three most proximal genes in 3L heterochromatin have key roles in development, and indicate strong effects of combinations of genetic modifiers of PEV on het gene expression.
BIOSIS ID	2001.222068
Zoological Record ID
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Secondary IDs
Language of Publication	English
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ISBN
Parent Publication
Publication Type	Journal
Abbreviation	Genetica
Title	Genetica
Editors
Publication Year	1919-
ISBN/ISSN	0016-6707
Data from Reference
Aberrations (21)
	Df(3L)1-16 Df(3L)1-166 Df(3L)2-66 Df(3L)6B-29+Df(3R)6B-29 Df(3L)9-56 Df(3L)C-2 Df(3L)G-1 Df(3L)K-2 Df(3L)O-1 Df(3L)vtd² Df(3L)vtd³ Df(3L)vtd⁶ Df(3L)vtd⁷ Df(3L)vtd⁸ Df(3L)vtd¹⁰ Df(3L)vtd¹¹ Df(3L)vtd¹² Df(3L)γ-26 Df(3L)γ-28 Df(3L)γ-29 In(3L)vtd⁹
Alleles (27)
	l(3)80Fj^2-30 Pc^unspecified rl^unspecified RpL15³ RpL15^7-1 RpL15^8-1 RpL15⁷² RpL15^PΔ2 RpL15^PΔ8 RpL15^unspecified Su(var)2-1¹ Su(var)2-1²¹³ Su(var)2-1²¹⁴ Su(var)2-1²¹⁶ Su(var)205^unspecified Su(var)208^unspecified vtd^3-1 vtd⁴ vtd^5-1 vtd^5-2 vtd^5-3 vtd^80Fh-1 vtd^80Fh-5 vtd^80Fh-6 vtd^80Fh-35 vtd^80Fh-36 vtd^unspecified
Genes (15)
	l(3)80Fa l(3)80Fb l(3)80Fc l(3)80Fd l(3)80Fe l(3)80Ff l(3)80Fg l(3)80Fj Pc rl RpL15 Su(var)2-1 Su(var)205 Su(var)208 vtd
Insertions (8)
	P{}RpL15^7-1 P{}RpL15^8-1 P{}RpL15^PΔ2 P{}RpL15^PΔ8 P{}vtd^3-1 P{}vtd^5-1 P{}vtd^5-2 P{}vtd^5-3