Reference Report

Reference
Citation	Miller, D.F.B., Holtzman, S.L., Kalkbrenner, A., Kaufman, T.C. (2001). Homeotic Complex (Hox) gene regulation and homeosis in the mesoderm of the Drosophila melanogaster embryo: the roles of signal transduction and cell autonomous regulation. Mech. Dev. 102(1-2): 17--32. (Export to RIS)
FlyBase ID	FBrf0135875
Publication Type	Research paper
PubMed ID	11287178
PubMed Abstract	In this paper we evaluate homeosis and Homeotic Complex (Hox) regulatory hierarchies in the somatic and visceral mesoderm. We demonstrate that both Hox control of signal transduction and cell autonomous regulation are critical for establishing normal Hox expression patterns and the specification of segmental identity and morphology. We present data identifying novel regulatory interactions associated with the segmental register shift in Hox expression domains between the epidermis/somatic mesoderm and visceral mesoderm. A proposed mechanism for the gap between the expression domains of Sex combs reduced (Scr) and Antennapedia (Antp) in the visceral mesoderm is provided. Previously, Hox gene interactions have been shown to occur on multiple levels: direct cross-regulation, competition for binding sites at downstream targets and through indirect feedback involving signal transduction. We find that extrinsic specification of cell fate by signaling can be overridden by Hox protein expression in mesodermal cells and propose the term autonomic dominance for this phenomenon.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Alleles (16)
	abd-A^Scer\UAS.cGa Antp²⁵ Antp^Scer\UAS.cMb Dfd^Scer\UAS.cBa Ecol\lacZ^dpp.RD2 Ecol\lacZ^lab.1.2HZ Ecol\lacZ^lab.7.0.Th Ecol\lacZ^lab.7.6HZ Ecol\lacZ^NUC.Scer\UAS lab^Scer\UAS.cMa pb^Scer\UAS.cMa Scer\GAL4^how-24B Scer\GAL4^twi.PG Scr^Scer\UAS.cMa Ubx¹ Ubx^Scer\UAS.cMa
Constructs (7)
	P{1.2labHZ} P{7.6labHZ} P{dpp^shv-lacZ.RD2} P{GAL4-twi.G} P{p7.0labTh} P{UAS-lacZ.N} P{UAS-lacZ.NUC}
Genes (10)
	abd-A Antp Dfd Ecol\lacZ lab pb Scer\GAL4 Scr Ubx βTub60D
Insertions (1)
	P{GawB}how^24B