Reference Report

Reference
Citation	Hitier, R., Chaminade, M., Preat, T. (2001). The Drosophila castor gene is involved in postembryonic brain development. Mech. Dev. 103(1-2): 3--11. (Export to RIS)
FlyBase ID	FBrf0135883
Publication Type	Research paper
PubMed ID	11335107
PubMed Abstract	castor (cas) encodes a zink finger protein expressed in a subset of Drosophila embryonic neuroglioblasts where it controls neuronal differentiation. We show here that cas is expressed at larval and pupal stages in brain cell clusters where it participates in the elaboration of the adult structures. In particular using the MARCM system (mosaic analysis with a repressible cell marker), we show that cas is required postembryonically for correct axon pathfinding of the central complex (CX) and mushroom body (MB) neurons. The linotte (lio) gene encodes a transmembrane protein expressed at larval/pupal stage in a glial structure, the TIFR, and interacts with the no-bridge (nob) gene. We show that cas interacts genetically with lio and nob. These interactions do not involve direct transcription regulation but probably cellular communication processes.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Alleles (11)
	cas²⁹⁰ cas³⁹²¹ drl² drl^P1 drl^P3.765 Ecol\lacZ^Scer\UAS.cBa Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} nob^KS49 plx^Δ180 Scer\GAL4^c345 Scer\GAL4^cas-3921
Constructs (1)
	P{UAS-mCD8::GFP.L}
Genes (7)
	cas drl Mmus\Cd8a nob plx Scer\GAL4 T:Avic\GFP
Insertions (2)
	P{GAL4}c345 P{GAL4}cas³⁹²¹
Transcripts (3)
	drl^P3.765RA Scer\GAL4^c345RA Scer\GAL4^cas-3921RA