Reference Report

Reference
Citation	Kammermeier, L., Leemans, R., Hirth, F., Flister, S., Wenger, U., Walldorf, U., Gehring, W.J., Reichert, H. (2001). Differential expression and function of the Drosophila Pax6 genes eyeless and twin of eyeless in embryonic central nervous system development. Mech. Dev. 103(1-2): 71--78. (Export to RIS)
FlyBase ID	FBrf0135884
Publication Type	Research paper
PubMed ID	11335113
PubMed Abstract	We analyzed the expression and function of eyeless (ey) and twin of eyeless (toy) in the embryonic central nervous system (CNS) of Drosophila. Both genes are differentially expressed in specific neuronal subsets (but not in glia) in every CNS neuromere, and in the brain, specific cell populations co-expressing both proteins define a longitudinal domain which is intercalated between broad exclusive expression domains of ey and toy. Studies of genetic null alleles and dsRNA interference did not reveal any gross neuroanatomical effects of ey, toy, or ey/toy elimination in the embryonic CNS. In contrast, targeted misexpression of ey, but not of toy, resulted in profound axonal abnormalities in the embryonic ventral nerve cord and brain.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Aberrations (1)
	Df(4)O2
Alleles (14)
	Ecol\lacZ^{Scer\UAS.O.T:Btau\MAPT} ey^C7.20 ey^dsRNA.cKa ey^J5.71 ey^Scer\UAS.cHa oc^dsRNA.cKa Scer\GAL4^238Y Scer\GAL4^Dll-md23 Scer\GAL4^elav-C155 Scer\GAL4^insc-Mz1407 Scer\GAL4^sca-537.4 toy^dsRNA.cKa toy^G7.39 toy^Scer\UAS.cCa
Constructs (2)
	P{UAS-ey.H} P{UAS-toy.C}
Genes (14)
	Ecol\lacZ elav ems en ey Fas2 futsch lab oc repo Scer\GAL4 sli T:Btau\MAPT toy
Insertions (4)
	P{GawB}238Y P{GawB}Dll^md23 P{GawB}insc^Mz1407 P{GawB}sca^537.4