Reference Report

Reference
Citation	Beckstead, R., Ortiz, J.A., Sanchez, C., Prokopenko, S.N., Chambon, P., Losson, R., Bellen, H.J. (2001). Bonus, a Drosophila homolog of TIF1 proteins, interacts with nuclear receptors and can inhibit FTZ-F1-dependent transcription. Mol. Cell 7(4): 753--765. (Export to RIS)
FlyBase ID	FBrf0135890
Publication Type	Research paper
PubMed ID	11336699
PubMed Abstract	The Drosophila bonus (bon) gene encodes a homolog of the vertebrate TIF1 transcriptional cofactors. bon is required for male viability, molting, and numerous events in metamorphosis including leg elongation, bristle development, and pigmentation. Most of these processes are associated with genes that have been implicated in the ecdysone pathway, a nuclear hormone receptor pathway required throughout Drosophila development. Bon is associated with sites on the polytene chromosomes and can interact with numerous Drosophila nuclear receptor proteins. Bon binds via an LxxLL motif to the AF-2 activation domain present in the ligand binding domain of betaFTZ-F1 and behaves as a transcriptional inhibitor in vivo.
DOI
Related Publication(s)
Supplementary material	Supplemental data. [FBrf0137448]
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Secondary IDs
Language of Publication	English
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Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Mol. Cell
Title	Molecular Cell
Publication Year	1997-
ISBN/ISSN	1097-2765 1097-4164
Data from Reference
Aberrations (2)
	Df(3L)Cat Df(3R)H-B79
Alleles (20)
	bon^{1-226.Act5C.T:Scer\GAL4} bon^{1-470.Act5C.T:Scer\GAL4} bon^{1-890.Act5C.T:Scer\GAL4} bon^{1-1133.Act5C.T:Scer\GAL4} bon^21B bon^{227-470.Act5C.T:Scer\GAL4} bon^{227-1133.Act5C.T:Scer\GAL4} bon^{471-890.Act5C.T:Scer\GAL4} bon^{471-890.Act5C.T:Zzzz\FLAG} bon^{471-1133.Act5C.T:Scer\GAL4} bon^{891-1133.Act5C.T:Scer\GAL4} bon^{Act5C.T:Zzzz\FLAG} bon^{Hsp83.T:Zzzz\FLAG} bon^S024108 bon^S024912 bon^S048706 Ecol\CAT^Scer\UAS.ERE ftz-f1^{555-802.Act5C.T:Scer\GAL4} ftz-f1^ex17 ftz-f1^{ΔAF-2ADcore.Act5C.T:Scer\GAL4}
Constructs (1)
	P{Hsp83-bon.FLAG}
Genes (10)
	bon br Ecol\CAT EcR Eip74EF ftz-f1 Hr46 T:Scer\GAL4 T:Zzzz\FLAG usp
Insertions (3)
	P{lacW}bon^S024108 P{lacW}bon^S024912 P{lacW}bon^S048706