Reference Report

Reference
Citation	Kusano, K., Johnson-Schlitz, D.M., Engels, W.R. (2001). Sterility of Drosophila with mutations in the Bloom syndrome gene-complementation by Ku70. Science 291(5513): 2600--2602. (Export to RIS)
FlyBase ID	FBrf0135945
Publication Type	Research paper
PubMed ID	11283371
PubMed Abstract	The Drosophila Dmblm locus is a homolog of the human Bloom syndrome gene, which encodes a helicase of the RECQ family. We show that Dmblm is identical to mus309, a locus originally identified in a mutagen-sensitivity screen. One mus309 allele, which carries a stop codon between two of the helicase motifs, causes partial male sterility and complete female sterility. Mutant males produce an excess of XY sperm and nullo sperm, consistent with a high frequency of nondisjunction and/or chromosome loss. These phenotypes of mus309 suggest that Dmblm functions in DNA double-strand break repair. The mutant Dmblm phenotypes were partially rescued by an extra copy of the DNA repair gene Ku70, indicating that the two genes functionally interact in vivo.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Science
Title	Science
Publication Year	1895-
ISBN/ISSN	0036-8075
Data from Reference
Aberrations (4)
	Df(3R)pros235 Df(3R)pros640 Df(3R)T-7 Df(3R)thoR1
Alleles (10)
	Blm^D2 Blm^D3 Blm^hs.PK Csk^j1D8 glo^S011046 Hsap\XRCC6^hs.PB Irbp^+t8.8 pros^S067102 tho¹ w^+mC
Constructs (3)
	P{gIRBP8.8} P{hs-blm.K} P{hs-Ku70.B}
Genes (8)
	Blm Csk glo Hsap\XRCC6 Irbp pros tho w
Insertions (6)
	P{3'lacW}Csk^j1D8 P{hs-blm.K}12-2 P{hs-blm.K}18-8 P{lacW}glo^S011046 P{lacW}pros^S067102 P{PZ}tho¹