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Reference Report
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| Citation | Wang, Y., Zhang, W., Jin, Y., Johansen, J., Johansen, K.M. (2001). The JIL-1 tandem kinase mediates histone H3 phosphorylation and is required for maintenance of chromatin structure in Drosophila. Cell 105(4): 433--443. (Export to RIS) | ||
| FlyBase ID | FBrf0136815 | ||
| Publication Type | Research paper | ||
| PubMed ID | 11371341 | ||
| PubMed Abstract | To analyze the function of the chromosomal kinase JIL-1, we generated an allelic series of hypomorphic and null mutations. JIL-1 is an essential kinase for viability, and reduced levels of JIL-1 kinase activity lead to a global change in chromatin structure. In JIL-1 hypomorphs, euchromatic regions of polytene chromosomes are severely reduced and the chromosome arms condensed. This is correlated with decreased levels of histone H3 Ser10 phosphorylation. These levels can be restored by a JIL-1 transgene placing JIL-1 directly in the pathway mediating histone H3 phosphorylation. We propose a model where JIL-1 kinase activity is required for maintaining the structure of the more open chromatin regions that facilitate gene transcription. | ||
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| FB2013_03 | |||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Cell | ||
| Title | Cell | ||
| Publication Year | 1974- | ||
| ISBN/ISSN | 0092-8674 | ||
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Data from Reference
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| Alleles (6)
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| Constructs (2)
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| Genes (9)
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| Insertions (5)
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