Reference Report

Reference
Citation	Ciapponi, L., Jackson, D.B., Mlodzik, M., Bohmann, D. (2001). Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites. Genes Dev. 15(12): 1540--1553. (Export to RIS)
FlyBase ID	FBrf0136943
Publication Type	Research paper
External Crossreferences
PubMed ID	11410534
PubMed Abstract	During Drosophila development Fos acts downstream from the JNK pathway. Here we show that it can also mediate ERK signaling in wing vein formation and photoreceptor differentiation. Drosophila JNK and ERK phosphorylate D-Fos with overlapping, but distinct, patterns. Analysis of flies expressing phosphorylation site point mutants of D-Fos revealed that the transcription factor responds differentially to JNK and ERK signals. Mutations in the phosphorylation sites for JNK interfere specifically with the biological effects of JNK activation, whereas mutations in ERK phosphorylation sites affect responses to the EGF receptor-Ras-ERK pathway. These results indicate that the distinction between ERK and JNK signals can be made at the level of D-Fos, and that different pathway-specific phosphorylated forms of the protein can elicit different responses.
BIOSIS ID	2001.324354
Zoological Record ID
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Secondary IDs
Language of Publication	English
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ISBN
Parent Publication
Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Editors
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Alleles (21)
	Egfr^E3 fz^Scer\UAS.cAa kay¹ kay² kay^{C-Ala.Scer\UAS} kay^Fbz.Scer\UAS kay^hs.PZ kay^{N-Ala.Scer\UAS} kay^{pan-Ala.Scer\UAS} kay^Scer\UAS.cEa rl^{Sem.C.Scer\UAS} rl^Sem Scer\GAL4^32B Scer\GAL4^69B Scer\GAL4^dpp.blk1 Scer\GAL4^en-e16E Scer\GAL4^h-1J3 Scer\GAL4^hs.2sev Scer\GAL4^sd-SG29.1 Scer\GAL4^unspecified sev^{S11.T:Hsap\MYC}
Constructs (11)
	P{GAL4-dpp.blk1} P{GAL4-Hsp70.sev} P{hs-kay.Z} P{sev5} P{UAS-D-fos^C-Ala} P{UAS-D-fos^N-Ala} P{UAS-D-fos^pan-Ala} P{UAS-Fra.Fbz} P{UAS-Fra} P{UAS-fz.A} P{UAS-rl^Sem}
Genes (7)
	Egfr fz kay rl Scer\GAL4 sev T:Hsap\MYC
Insertions (5)
	P{en2.4-GAL4}e16E P{GawB}32B P{GawB}69B P{GawB}h^1J3 P{GawB}sd^SG29.1