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Citation
Hewes, R.S., Taghert, P.H. (2001). Neuropeptides and neuropeptide receptors in the Drosophila melanogaster genome.  Genome Res. 11(6): 1126--1142.
FlyBase ID
FBrf0136958
Publication Type
Research paper
Abstract
Recent genetic analyses in worms, flies, and mammals illustrate the importance of bioactive peptides in controlling numerous complex behaviors, such as feeding and circadian locomotion. To pursue a comprehensive genetic analysis of bioactive peptide signaling, we have scanned the recently completed Drosophila genome sequence for G protein-coupled receptors sensitive to bioactive peptides (peptide GPCRs). Here we describe 44 genes that represent the vast majority, and perhaps all, of the peptide GPCRs encoded in the fly genome. We also scanned for genes encoding potential ligands and describe 22 bioactive peptide precursors. At least 32 Drosophila peptide receptors appear to have evolved from common ancestors of 15 monophyletic vertebrate GPCR subgroups (e.g., the ancestral gastrin/cholecystokinin receptor). Six pairs of receptors are paralogs, representing recent gene duplications. Together, these findings shed light on the evolutionary history of peptide GPCRs, and they provide a template for physiological and genetic analyses of peptide signaling in Drosophila.
PubMed ID
PubMed Central ID
PMC311076 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase
Sequence of Drosophila melanogaster peptide GPCRs.
Hewes and Taghert, 2001.7.31, Sequence of Drosophila melanogaster peptide GPCRs. [FBrf0137441]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genome Res.
    Title
    Genome Research
    Publication Year
    1995-
    ISBN/ISSN
    1088-9051
    Data From Reference