Reference Report

Reference
Citation	Mishra, A., Agrawal, N., Banerjee, S., Sardesai, D., Dalal, J.S., Bhojwani, J., Sinha, P. (2001). Spatial regulation of DELTA expression mediates NOTCH signalling for segmentation of Drosophila legs. Mech. Dev. 105(1-2): 115--127. (Export to RIS)
FlyBase ID	FBrf0137014
Publication Type	Research paper
PubMed ID	11429287
PubMed Abstract	The Notch (N) signalling pathway is recruited for segregation of cell fates in a number of Drosophila tissue types. We show here that N dependent segmentation of Drosophila legs is regulated by a dynamic pattern of expression of its ligand, DELTA (DL). During third larval instar and early stages of pupation, high levels of DL expression is seen in stripes of cells in the leg imaginal discs which later form the proximal borders of leg joints. These domains also displayed heightened Dl enhancer activity. During subsequent stages of pupation, following segmentation of the leg primordium, DL expression becomes uniform throughout these segments barring the joints. We further show that regulatory Dl mutations or mis-expression of DL abolish leg segmentation. Domains of N signalling for segmentation of legs of flies are thus set up by a stringent spatial regulation of expression of its ligand at the segment border. Further, a comparable role of DL in antennal development reveals a common paradigm of DL-N signalling for segmentation of appendages in flies.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Alleles (11)
	Dl⁰⁵¹⁵¹ Dl^B107 Dl^bl1 Dl^bl5 Dl^blX59 Dl^FE30 Dl^FE32 Dl^Scer\UAS.cDa N^l1N-ts1 Scer\GAL4^ap-md544 Scer\GAL4^Dll-md23
Constructs (1)
	P{UAS-Dl.D}
Genes (3)
	Dl N Scer\GAL4
Insertions (4)
	P{GawB}ap^md544 P{GawB}Dll^md23 P{lacW}Dl^bl1 P{PZ}Dl⁰⁵¹⁵¹