Reference Report

Reference
Citation	King, F.J., Szakmary, A., Cox, D.N., Lin, H. (2001). Yb modulates the divisions of both germline and somatic stem cells through piwi- and hh-mediated mechanisms in the Drosophila ovary. Mol. Cell 7(3): 497--508. (Export to RIS)
FlyBase ID	FBrf0137038
Publication Type	Research paper
PubMed ID	11463375
PubMed Abstract	The coordinated division of distinctive types of stem cells within an organ is crucial for organogenesis and homeostasis. Here we show genetic interactions among fs(1)Yb (Yb), piwi, and hedgehog (hh) that regulate the division of both germline stem cells (GSCs) and somatic stem cells (SSCs), the two constituent stem cell populations of the Drosophila ovary. Yb is required for both GSC and SSC divisions; loss of Yb function eliminates GSCs and reduces SSC division, while Yb overexpression increases GSC number and causes SSC overproliferation. We also show that Yb acts via the piwi- and hh-mediated signaling pathways that emanate from the same signaling cells to control GSC and SSC division, respectively. hh signaling also has a minor effect in GSC division.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mol. Cell
Title	Molecular Cell
Publication Year	1997-
ISBN/ISSN	1097-2765 1097-4164
Data from Reference
Alleles (17)
	fs(1)Yb¹ fs(1)Yb⁷² fs(1)Yb^{hs.T:Zzzz\His6,T:Zzzz\FLAG} fs(1)Yb^M104-1 fs(1)Yb^M104-3 fs(1)Yb^Scer\UAS.cKa fs(1)Yb^unspecified hh⁴ hh¹¹ hh^hs.PI hh^Scer\UAS.cAa piwi¹ piwi² piwi^5'T:Hsap\MYC piwi^EP1024 ptc¹⁶ Scer\GAL4^hs.PB
Constructs (6)
	P{5'-myc-piwi} P{GAL4-Hsp70.PB} P{HShh.I} P{hs-Yb.His6,FLAG} P{UAS-hh.A} P{UAS-Yb.K}
Genes (9)
	fs(1)Yb hh piwi ptc Scer\GAL4 T:Hsap\MYC T:Zzzz\FLAG T:Zzzz\His6 vas