Reference Report

Reference
Citation	Gim, B.S., Park, J.M., Yoon, J.H., Kang, C., Kim, Y.J. (2001). Drosophila med6 is required for elevated expression of a large but distinct set of developmentally regulated genes. Mol. Cell. Biol. 21(15): 5242--5255. (Export to RIS)
FlyBase ID	FBrf0137044
Publication Type	Research paper
PubMed ID	11438678
PubMed Abstract	Mediator is the evolutionarily conserved coactivator required for the integration and recruitment of diverse regulatory signals to basal transcription machinery. To elucidate the functions of metazoan Mediator, we isolated Drosophila melanogaster Med6 mutants. dMed6 is essential for viability and/or proliferation of most cells. dMed6 mutants failed to pupate and died in the third larval instar with severe proliferation defects in imaginal discs and other larval mitotic cells. cDNA microarray, quantitative reverse transcription-PCR, and in situ expression analyses of developmentally regulated genes in dMed6 mutants showed that transcriptional activation of many, but not all, genes was affected. Among the genes found to be affected were some that play a role in cell proliferation and metabolism. Therefore, dMed6 is required in most cells for transcriptional regulation of many genes important for diverse aspects of Drosophila development.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mol. Cell. Biol.
Title	Molecular and Cellular Biology
Publication Year	1981-
ISBN/ISSN	0270-7306
Data from Reference
Aberrations (2)
	Df(3R)by10 Df(3R)GB104
Alleles (4)
	MED6²⁶ MED6⁶⁴ MED6^+t10.4 MED6^unspecified
Constructs (1)
	P{MED6^+t10.4}
Genes (102)
	14-3-3ζ 18w Abl ac Adh Ald Ama Antp ap apt ash1 Awh brm cact CalpA Cam cdc2 Cdk8 CG8117 Clk CrebA csw CycE dap dib dl Dll dpp drk Ecol\lacZ Egfr Eip75B esc exd fkh Gpdh gro Gs2 H hh how Hr78 Hsf Hsp22 Hsp27 ImpE2 ImpL3 Itp-r83A Kr kto l(1)sc Lsp1β Med MED4 MED6 MED17 MED18 MED20 MED21 MED24 MED25 MED27 MED31 Mef2 mof Nrg orb Pgd piwi Pka-C1 Pp2A-29B pros psq PyK Ras85D RasGAP1 Rel rl roX1 Rpd3 RpL32 salm sax scrt scw sgl skd sna Sos sqd stg sty Su(var)205 tkv tok Trl trx Tudor-SN Ubi-p63E Vha55 z zip
Natural transposons (1)
	P-element