Reference Report

Reference
Citation	Bellaiche, Y., Radovic, A., Woods, D.F., Hough, C.D., Parmentier, M., O'Kane, C.J., Bryant, P.J., Schweisguth, F. (2001). The partner of inscuteable/discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila. Cell 106(3): 355--366. (Export to RIS)
FlyBase ID	FBrf0137190
Publication Type	Research paper
PubMed ID	11509184
PubMed Abstract	Frizzled (Fz) signaling regulates cell polarity in both vertebrates and invertebrates. In Drosophila, Fz orients the asymmetric division of the sensory organ precursor cell (pI) along the antero-posterior axis of the notum. Planar polarization involves a remodeling of the apical-basal polarity of the pI cell. The Discs-large (Dlg) and Partner of Inscuteable (Pins) proteins accumulate at the anterior cortex, while Bazooka (Baz) relocalizes to the posterior cortex. Dlg interacts directly with Pins and regulates the localization of Pins and Baz. Pins acts with Fz to localize Baz posteriorly, but Baz is not required to localize Pins anteriorly. Finally, Baz and the Dlg/Pins complex are required for the asymmetric localization of Numb. Thus, the Dlg/Pins complex responds to Fz signaling to establish planar asymmetry in the pI cell.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (12)
	Avic\GFP^{Scer\UAS.m6.T:Btau\MAPT} baz⁴ dlg1¹² dlg1¹⁸ dlg1^sw fz³⁰ fz³⁷ Hsap\HIST2H2BE^{Scer\UAS.T:Avic\GFP-YFP} insc^Scer\UAS.cKa raps^Δ50 Scer\GAL4^neur-P72 T:Avic\GFP^YFP
Constructs (3)
	P{UAS-H2B-T:Avic\GFP-YFP} P{UAS-insc.K} P{UAS-Tau-GFP.m6}
Genes (26)
	Avic\GFP baz cno cora crb ct dlg1 Fas3 fz Hsap\HIST2H2BE insc l(2)gl numb Patj pon raps Scer\GAL4 shg T:Avic\GFP T:Btau\MAPT α-Spec αTub67C αTub84B αTub84D αTub85E β-Spec
Insertions (1)
	P{GAL4}neur^P72