Reference Report

Reference
Citation	Punzo, C., Kurata, S., Gehring, W.J. (2001). The eyeless homeodomain is dispensable for eye development in Drosophila. Genes Dev. 15(13): 1716--1723. (Export to RIS)
FlyBase ID	FBrf0137241
Publication Type	Research paper
PubMed ID	11445545
PubMed Abstract	Pax-6 genes, known to be essential for eye development, encode an evolutionarily conserved transcription factor with two DNA-binding domains. To corroborate the contribution of each DNA-binding domain to eye formation, we generated truncated forms of the Drosophila Pax-6 gene eyeless and tested their capacity to rescue the ey(2) mutant. Surprisingly, EY deleted of the homeodomain rescued the ey(2) mutant and triggered ectopic eyes morphogenesis. In contrast, EY lacking the paired domain failed to rescue the ey(2) mutant, led to truncation of appendages, and repressed Distal-less when misexpressed. This result suggests distinct functions mediated differentially by the two DNA-binding domains of eyeless.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Alleles (10)
	Ecol\lacZ^so-7 ey² ey^J5.71 ey^Scer\UAS.cHa ey^{ΔHD.Scer\UAS} ey^{ΔPD.Scer\UAS} ey^{ΔPD+ΔHD.Scer\UAS} ey^{ΔPDPMHD.Scer\UAS} ninaE^unspecified Scer\GAL4^ey.PH
Constructs (6)
	P{GAL4-ey.H} P{UAS-ey.H} P{UAS-ey.ΔHD} P{UAS-ey.ΔPD} P{UAS-ey.ΔPD+ΔHD} P{UAS-ey.ΔPDPMHD}
Genes (7)
	dac Dll Ecol\lacZ ey ninaE Scer\GAL4 so
Insertions (1)
	P{A92}so⁷