Reference Report

Reference
Citation	Grosjean, Y., Balakireva, M., Dartevelle, L., Ferveur, J.F. (2001). PGal4 excision reveals the pleiotropic effects of Voila, a Drosophila locus that affects development and courtship behaviour. Genet. Res. (Camb.) 77(3): 239--250. (Export to RIS)
FlyBase ID	FBrf0137245
Publication Type	Research paper
PubMed ID	11486507
PubMed Abstract	In Drosophila melanogaster, the PGal4 transposon inserted at the chromosomal site 86E1-2 is associated with the Voila1 allele that causes multiple phenotypes. Homozygous Voila1/1 flies rarely reach adulthood and heterozygous Voila1/+ adult males display strong homosexual courtship behaviour. Both normal behavioural and developmental phenotypes were rescued by remobilizing the PGal4 element. Yet, the rescue of heterosexual courtship and of adult viability did not occur in the same strains, indicating that these defects have different genetic origins. Furthermore, many strains showed a partial rescue of both characters. Molecular analysis revealed that the PGal4 transposon is inserted upstream of the 5'UTR of the prospero gene. The excision strains with no detectable fragment of the PGal4 transposon remaining showed a rescued viability for homozygote adults. Moreover, the developmental period with the highest homozygote lethality was correlated with the size of PGal4 element that remained inserted at the Voila locus. This suggests a relationship between developmental viability and the amount of DNA inserted within the promoter of prospero.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genet. Res. (Camb.)
Title	Genetics research
Publication Year	1960-
ISBN/ISSN	0016-6723 1469-5073
Data from Reference
Alleles (62)
	pros^V1 pros^V2 pros^V3 pros^V4 pros^V5 pros^V6 pros^V7 pros^V8 pros^V9 pros^V10 pros^V11 pros^V12 pros^V13 pros^V14 pros^V15 pros^V16 pros^V17 pros^V18 pros^V19 pros^V20 pros^V21 pros^V23 pros^V24 pros^V25 pros^V26 pros^V27 pros^V28 pros^V29 pros^V30 pros^V31 pros^V35 pros^V36 pros^V37 pros^V38 pros^V39 pros^V41 pros^V43 pros^V45 pros^V48 pros^V49 pros^V50 pros^V51 pros^V52 pros^V54 pros^V56 pros^V57 pros^V58 pros^V59 pros^V60 pros^V61 pros^V62 pros^V63 pros^V64 pros^V65 pros^V66 pros^V67 pros^V68 pros^V69 pros^V70 pros^V75 pros^V78 pros^V79
Constructs (13)
	P{?GawB} P{GawB} P{GawB-Δ2.G} P{GawB-Δ3.G} P{GawB-Δ8.G} P{GawB-Δ11.G} P{GawB-Δ13.G} P{GawB-Δ24.G} P{GawB-Δ27.G} P{GawB-Δ61.G} P{GawB-Δ69.G} P{GawB-Δ78.G} P{GawB-Δ79.G}
Genes (1)
	pros
Insertions (59)
	P{5'3'}pros^V26 P{5'3'}pros^V28 P{5'3'}pros^V60 P{5'3'}pros^V65 P{?GawB}pros^V4 P{?GawB}pros^V5 P{?GawB}pros^V6 P{?GawB}pros^V7 P{?GawB}pros^V9 P{?GawB}pros^V10 P{?GawB}pros^V12 P{?GawB}pros^V15 P{?GawB}pros^V16 P{?GawB}pros^V17 P{?GawB}pros^V18 P{?GawB}pros^V19 P{?GawB}pros^V20 P{?GawB}pros^V21 P{?GawB}pros^V23 P{?GawB}pros^V25 P{?GawB}pros^V29 P{?GawB}pros^V30 P{?GawB}pros^V31 P{?GawB}pros^V35 P{?GawB}pros^V36 P{?GawB}pros^V37 P{?GawB}pros^V38 P{?GawB}pros^V39 P{?GawB}pros^V41 P{?GawB}pros^V43 P{?GawB}pros^V48 P{?GawB}pros^V49 P{?GawB}pros^V50 P{?GawB}pros^V51 P{?GawB}pros^V52 P{?GawB}pros^V54 P{?GawB}pros^V56 P{?GawB}pros^V57 P{?GawB}pros^V58 P{?GawB}pros^V59 P{?GawB}pros^V62 P{?GawB}pros^V63 P{?GawB}pros^V66 P{?GawB}pros^V67 P{?GawB}pros^V68 P{?GawB}pros^V70 P{?GawB}pros^V75 P{GawB}pros^V1 P{GawB-Δ2.G}pros^V2 P{GawB-Δ3.G}pros^V3 P{GawB-Δ8.G}pros^V8 P{GawB-Δ11.G}pros^V11 P{GawB-Δ13.G}pros^V13 P{GawB-Δ24.G}pros^V24 P{GawB-Δ27.G}pros^V27 P{GawB-Δ61.G}pros^V61 P{GawB-Δ69.G}pros^V69 P{GawB-Δ78.G}pros^V78 P{GawB-Δ79.G}pros^V79