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Saitoe, M., Schwarz, T.L., Umbach, J.A., Gundersen, C.B., Kidokoro, Y. (2001). Absence of junctional glutamate receptor clusters in Drosophila mutants lacking spontaneous transmitter release.  Science 293(5529): 514--517.
FlyBase ID
FBrf0137363
Publication Type
Research paper
Abstract

Little is known about the functional significance of spontaneous miniature synaptic potentials, which are the result of vesicular exocytosis at nerve terminals. Here, by using Drosophila mutants with specific defects in presynaptic function, we found that glutamate receptors clustered normally at neuromuscular junctions of mutants that retained spontaneous transmitter secretion but had lost the ability to release transmitter in response to action potentials. In contrast, receptor clustering was defective in mutants in which both spontaneous and evoked vesicle exocytosis were absent. Thus, spontaneous vesicle exocytosis appears to be tightly linked to the clustering of glutamate receptors during development.

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The meaning of a mini.
Verstreken and Bellen, 2001, Science 293(5529): 443--444 [FBrf0137362]

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075
    Data From Reference
    Alleles (8)
    Genes (9)
    Insertions (1)
    Transgenic Constructs (3)
    Transcripts (2)