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Citation
Anholt, R.R., Mackay, T.F.C. (2001). The genetic architecture of odor-guided behavior in Drosophila melanogaster.  Behav. Genet. 31(1): 17--27.
FlyBase ID
FBrf0138231
Publication Type
Research paper
Abstract
The avoidance response to repellent odorants in Drosophila melanogaster, a response essential for survival, provides an advantageous model for studies on the genetic architecture of behavior. Transposon tagging in a highly inbred strain of flies in combination with a rapid and simple statistical behavioral assay enables the identification of not only large phenotypic effects, but also small aberrations from wild-type avoidance behavior. The recent completion of the sequence of the Drosophila genome facilitates the molecular characterization of transposon-tagged genes and correlation between gene expression and behavior in smell-impaired (smi) mutant lines. Quantitative genetic analyses of a collection of smi lines in a coisogenic background revealed an extensive network of epistatic interactions among genes that shape the olfactory avoidance response. The identification and functional characterization of proteins encoded by smi genes that form part of the olfactory subgenome and correlation of polymorphisms in these genes with variation in odor-guided behavior in natural populations will advance our understanding of the genetic architecture of chemosensory behavior.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Behav. Genet.
    Title
    Behavior Genetics
    Publication Year
    1970-
    ISBN/ISSN
    0001-8244
    Data From Reference