Reference Report

Reference
Citation	Greco, V., Hannus, M., Eaton, S. (2001). Argosomes. A potential vehicle for the spread of morphogens through epithelia. Cell 106(5): 633--645. (Export to RIS)
FlyBase ID	FBrf0138253
Publication Type	Research paper
PubMed ID	11551510
PubMed Abstract	The formation of morphogen gradients is essential for tissue patterning. Morphogens are released from producing cells and spread through adjacent tissue; paradoxically, however, many morphogens, including Wingless, associate tightly with the cell membrane. Here, we describe a novel cell biological mechanism that disperses membrane fragments over large distances through the Drosophila imaginal disc epithelium. We call these membrane exovesicles argosomes. Argosomes are derived from basolateral membranes and are produced by many different regions of the disc. They travel through adjacent tissue where they are found predominantly in endosomes. Wingless protein colocalizes with argosomes derived from Wingless-producing cells. The properties of argosomes are consistent with their being a vehicle for the spread of Wingless protein.
DOI
Related Publication(s)
Review	Wingless and the argosomes. Wells, 2001, J. Cell Biol. 155(1): 12 [FBrf0139880]
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (12)
	Avic\GFP^Scer\UAS.cUa Avic\GFP^{Scer\UAS.T:Hsap\Myr2} Avic\GFP^{Scer\UAS.T:Ocun\LPH-ss,T:Hsap\LFA3-GPI} Rho1^{Scer\UAS:T:Avic\GFP-CFP} Scer\GAL4^ap-md544 Scer\GAL4^brk-3sB Scer\GAL4^en-e16E Scer\GAL4^ptc-559.1 Scer\GAL4^wg.PM T:Avic\GFP^CFP T:Hsap\LFA3^GPI T:Ocun\LPH^ss
Constructs (5)
	P{GAL4-wg.M} P{UAS-gapGFP} P{UAS-GFP.gpi} P{UAS-GFP.U} P{UAS-Rho1.CFP}
Genes (9)
	Avic\GFP brk Rho1 Scer\GAL4 T:Avic\GFP T:Hsap\LFA3 T:Hsap\Myr2 T:Ocun\LPH wg
Insertions (4)
	P{en2.4-GAL4}e16E P{GAL4}brk^3sB P{GawB}ap^md544 P{GawB}ptc^559.1
Transcripts (1)
	Scer\GAL4^brk-3sBRA