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Citation
Butler, H., Levine, S., Wang, X., Bonyadi, S., Fu, G., Lasko, P., Suter, B., Doerig, R. (2001). Map position and expression of the genes in the 38 region of Drosophila.  Genetics 158(4): 1597--1614.
FlyBase ID
FBrf0138405
Publication Type
Research paper
Abstract

With the completion of the Drosophila genome sequence, an important next step is to extract its biological information by systematic functional analysis of genes. We have produced a high-resolution genetic map of cytological region 38 of Drosophila using 41 deficiency stocks that provide a total of 54 breakpoints within the region. Of a total of 45 independent P-element lines that mapped by in situ hybridization to the region, 14 targeted 7 complementation groups within the 38 region. Additional EMS, X-ray, and spontaneous mutations define a total of 17 complementation groups. Because these two pools partially overlap, the completed analysis revealed 21 distinct complementation groups defined by point mutations. Seven additional functions were defined by trans-heterozygous combinations of deficiencies, resulting in a total of 28 distinct functions. We further produced a developmental expression profile for the 760 kb from 38B to 38E. Of 135 transcription units predicted by GENSCAN, 22 have at least partial homology to mobile genetic elements such as transposons and retroviruses and 17 correspond to previously characterized genes. We analyzed the developmental expression pattern of the remaining genes using poly(A)(+) RNA from ovaries, early and late embryos, larvae, males, and females. We discuss the correlation between GENSCAN predictions and experimentally confirmed transcription units, the high number of male-specific transcripts, and the alignment of the genetic and physical maps in cytological region 38.

PubMed ID
PubMed Central ID
PMC1461758 (PMC) (EuropePMC)
DOI
Related Publication(s)
Personal communication to FlyBase

FASTA sequences of Gene Predictions of the 38 region.
McGill Drosophila Genome Project, 2001.9.25, FASTA sequences of Gene Predictions of the 38 region. [FBrf0139855]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetics
    Title
    Genetics
    Publication Year
    1916-
    ISBN/ISSN
    0016-6731
    Data From Reference
    Aberrations (46)
    Alleles (51)
    Balancers (3)
    Genes (139)
    Natural transposons (13)
    Insertions (29)