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Citation
Furlong, E.E.M., Andersen, E.C., Null, B., White, K.P., Scott, M.P. (2001). Patterns of gene expression during Drosophila mesoderm development.  Science 293(5535): 1629--1633.
FlyBase ID
FBrf0138533
Publication Type
Research paper
Abstract

The transcription factor Twist initiates Drosophila mesoderm development, resulting in the formation of heart, somatic muscle, and other cell types. Using a Drosophila embryo sorter, we isolated enough homozygous twist mutant embryos to perform DNA microarray experiments. Transcription profiles of twist loss-of-function embryos, embryos with ubiquitous twist expression, and wild-type embryos were compared at different developmental stages. The results implicate hundreds of genes, many with vertebrate homologs, in stage-specific processes in mesoderm development. One such gene, gleeful, related to the vertebrate Gli genes, is essential for somatic muscle development and sufficient to cause neural cells to express a muscle marker.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075
    Data From Reference
    Aberrations (1)
    Alleles (4)
    Genes (93)
    Natural transposons (2)
    Insertions (1)
    Experimental Tools (1)
    Transgenic Constructs (1)