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Citation
Selva, E.M., Hong, K., Baeg, G.H., Beverley, S.M., Turco, S.J., Perrimon, N., Hacker, U. (2001). Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events.  Nat. Cell Biol. 3(9): 809--815.
FlyBase ID
FBrf0138544
Publication Type
Research paper
Abstract
The precise regulation of growth factor signalling is crucial to the molecular control of development in Drosophila. Post-translational modification of signalling molecules is one of the mechanisms that modulate developmental signalling specificity. We describe a new gene, fringe connection (frc), that encodes a nucleotide-sugar transporter that transfers UDP-glucuronic acid, UDP-N-acetylglucosamine and possibly UDP-xylose from the cytoplasm into the lumen of the endoplasmic reticulum/Golgi. Embryos with the frc mutation display defects in Wingless, Hedgehog and fibroblast growth factor signalling. Clonal analysis shows that fringe-dependent Notch signalling is disrupted in frc mutant tissue.
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PubMed Central ID
Related Publication(s)
Review
Sugar-coated pathways for developmental patterning.
Fortini, 2001, Nat. Cell Biol. 3(10): E229--E231 [FBrf0159807]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Cell Biol.
    Title
    Nature Cell Biology
    Publication Year
    1999-
    ISBN/ISSN
    1465-7392 1476-4679
    Data From Reference
    Aberrations (1)
    Alleles (11)
    Genes (10)
    Insertions (2)
    Experimental Tools (1)
    Transgenic Constructs (5)