Reference Report

Reference
Citation	Deshpande, G., Swanhart, L., Chiang, P., Schedl, P. (2001). Hedgehog signaling in germ cell migration. Cell 106(6): 759--769. (Export to RIS)
FlyBase ID	FBrf0139603
Publication Type	Research paper
PubMed ID	11572781
PubMed Abstract	The primitive gonad of the Drosophila embryo is formed from two cell types, the somatic gonad precursor cells (SGPs) and the germ cells, which originate at distant sites. To reach the SGPs the germ cells must undergo a complex series of cell movements. While there is evidence that attractive and repulsive signals guide germ cell migration through the embryo, the molecular identity of these instructive molecules has remained elusive. Here, we present evidence suggesting that hedgehog (hh) may serve as such an attractive guidance cue. Misexpression of hh in the soma induces germ cells to migrate to inappropriate locations. Conversely, cell-autonomous components of the hh pathway appear to be required in the germline for proper germ cell migration.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (13)
	Ecol\lacZ^hh-P30 Ecol\lacZ^Scer\UAS.cUa fu^mH63 hh^Scer\UAS.cIa Pka-C1^H2 ptc^ptcII Scer\GAL4^elav.PLu Scer\GAL4^h-1J3 Scer\GAL4^how-24B Scer\GAL4^nos.PG Scer\GAL4^twi.PG smo² wg^Scer\UAS.cLa
Constructs (6)
	P{GAL4-elav.L} P{GAL4-nos.NGT} P{GAL4-twi.G} P{UAS-hh.I} P{UAS-lacZ.U} P{UAS-wg.L}
Genes (11)
	Ecol\lacZ en eya fu hh Pka-C1 ptc Scer\GAL4 smo vas wg
Insertions (3)
	P{GawB}h^1J3 P{GawB}how^24B P{PZ}hh^P30