Milan, M., Weihe, U., Perez, L., Cohen, S.M. (2001). The LRR proteins Capricious and Tartan mediate cell interactions during DV boundary formation in the Drosophila wing.  Cell 106(6): 785--794.

FBrf0139604

Research paper

Mechanisms to segregate cell populations play important roles in tissue patterning during animal development. Rhombomeres and compartments in the ectoderm and imaginal discs of Drosophila are examples in which initially homogenous populations of cells come to be separated by boundaries of lineage restriction. Boundary formation depends in part on signaling between the distinctly specified cell populations that comprise compartments and in part on formation of affinity boundaries that prevent intermingling of these cell populations. Here, we present evidence that two transmembrane proteins with leucine-rich repeats, known as Capricious and Tartan, contribute to formation of the affinity boundary between dorsal and ventral compartments during Drosophila wing development.