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Citation
Billuart, P., Winter, C.G., Maresh, A., Zhao, X., Luo, L. (2001). Regulating axon branch stability. The role of p190 RhoGAP in repressing a retraction signaling pathway.  Cell 107(2): 195--207.
FlyBase ID
FBrf0139610
Publication Type
Research paper
Abstract

Mechanisms that regulate axon branch stability are largely unknown. Genome-wide analyses of Rho GTPase activating protein (RhoGAP) function in Drosophila using RNA interference identified p190 RhoGAP as essential for axon stability in mushroom body neurons, the olfactory learning and memory center. p190 inactivation leads to axon branch retraction, a phenotype mimicked by activation of GTPase RhoA and its effector kinase Drok and modulated by the level and phosphorylation of myosin regulatory light chain. Thus, there exists a retraction pathway from RhoA to myosin in maturing neurons, which is normally repressed by p190. Local regulation of p190 could control the structural plasticity of neurons. Indeed, genetic evidence supports negative regulation of p190 by integrin and Src, both implicated in neural plasticity.

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Review

Staying connected.
Leslie, 2001, J. Cell Biol. 155(4): 497 [FBrf0141782]

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Aberrations (1)
    Alleles (47)
    Genes (31)
    Insertions (8)
    Experimental Tools (3)
    Transgenic Constructs (34)
    Transcripts (1)