Reference Report

Reference
Citation	Billuart, P., Winter, C.G., Maresh, A., Zhao, X., Luo, L. (2001). Regulating axon branch stability. The role of p190 RhoGAP in repressing a retraction signaling pathway. Cell 107(2): 195--207. (Export to RIS)
FlyBase ID	FBrf0139610
Publication Type	Research paper
PubMed ID	11672527
PubMed Abstract	Mechanisms that regulate axon branch stability are largely unknown. Genome-wide analyses of Rho GTPase activating protein (RhoGAP) function in Drosophila using RNA interference identified p190 RhoGAP as essential for axon stability in mushroom body neurons, the olfactory learning and memory center. p190 inactivation leads to axon branch retraction, a phenotype mimicked by activation of GTPase RhoA and its effector kinase Drok and modulated by the level and phosphorylation of myosin regulatory light chain. Thus, there exists a retraction pathway from RhoA to myosin in maturing neurons, which is normally repressed by p190. Local regulation of p190 could control the structural plasticity of neurons. Indeed, genetic evidence supports negative regulation of p190 by integrin and Src, both implicated in neural plasticity.
DOI
Related Publication(s)
Review	Staying connected. Leslie, 2001, J. Cell Biol. 155(4): 497 [FBrf0141782]
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Secondary IDs
Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (1)
	Df(1)BK10
Alleles (47)
	CdGAPr^{dsRNA.Scer\UAS} cv-c^{dsRNA.Scer\UAS} Graf^{dsRNA.Scer\UAS} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} mys¹ mys¹¹ mys^G0091b Rho1^72O Rho1^{dsRNA.Scer\UAS} Rho1^Scer\UAS.cMa Rho1^{V14.E40L.Scer\UAS} Rho1^{V14.F39V.Scer\UAS} Rho1^V14.Scer\UAS RhoGAP1A^{dsRNA.Scer\UAS} RhoGAP5A^{dsRNA.Scer\UAS} RhoGAP15B^{dsRNA.Scer\UAS} RhoGAP16F^{dsRNA.Scer\UAS} RhoGAP18B^{dsRNA.Scer\UAS} RhoGAP19D^{dsRNA.Scer\UAS} RhoGAP54D^{dsRNA.Scer\UAS} RhoGAP68F^{dsRNA.Scer\UAS} RhoGAP71E^unspecified RhoGAP92B^{dsRNA.Scer\UAS} RhoGAP93B^{dsRNA.Scer\UAS} RhoGAP100F^{dsRNA.Scer\UAS} RhoGAP102A^{dsRNA.Scer\UAS} RhoGAPp190^{dsRNA.GAP.Scer\UAS} RhoGAPp190^{dsRNA.N.Scer\UAS} RhoGAPp190^{mut.Scer\UAS.T:Hsap\MYC} RhoGAPp190^{R1389L.Scer\UAS.T:Hsap\MYC} RhoGAPp190^{Scer\UAS.T:Hsap\MYC} Rnor\p190^Scer\UAS.cBa rok² rok^CAT.Scer\UAS rok^{CAT-KG.Scer\UAS} scb^Vol-4 Scer\GAL4^ey.PB Scer\GAL4^ey-OK107 Scer\GAL4^T80 Scer\GAL4^αTub84B.PL sqh^{A21.T:Zzzz\FLAG} sqh^AX3 sqh^E20.E21 Src64B^BGT-T063 Src64B^PI tum^{dsRNA.Scer\UAS.cBa} w^+mC
Constructs (34)
	P{GAL4-ey.B} P{sqh-A21} P{sqh-E20E21} P{tubP-GAL4} P{UAS-CdGAPr-dsRNA} P{UAS-cv-c-dsRNA} P{UAS-Graf-dsRNA} P{UAS-mCD8::GFP.L} P{UAS-myc-RhoGAPp190.B} P{UAS-myc-RhoGAPp190.mut} P{UAS-myc-RhoGAPp190.R1389L} P{UAS-RacGAP50C-dsRNA} P{UAS-Rho1.Sph} P{UAS-Rho1.V14.E40L} P{UAS-Rho1.V14.F39V} P{UAS-Rho1.V14} P{UAS-Rho1-dsRNA} P{UAS-RhoGAP1A-dsRNA} P{UAS-RhoGAP5A-dsRNA} P{UAS-RhoGAP15B-dsRNA} P{UAS-RhoGAP16F-dsRNA} P{UAS-RhoGAP18B-dsRNA} P{UAS-RhoGAP19D-dsRNA} P{UAS-RhoGAP54D-dsRNA} P{UAS-RhoGAP68F-dsRNA} P{UAS-RhoGAP92B-dsRNA} P{UAS-RhoGAP93B-dsRNA} P{UAS-RhoGAP100F-dsRNA} P{UAS-RhoGAP102A-dsRNA} P{UAS-RhoGAPp190.GAP-dsRNA} P{UAS-RhoGAPp190.N-dsRNA} P{UAS-Rnor\p190.B} P{UAS-rok.CAT} P{UAS-rok.CAT-KG}
Genes (34)
	CdGAPr cv-c Fas2 Graf Mmus\Cd8a mys RacGAP84C Rho1 RhoGAP1A RhoGAP5A RhoGAP15B RhoGAP16F RhoGAP18B RhoGAP19D RhoGAP54D RhoGAP68F RhoGAP71E RhoGAP92B RhoGAP93B RhoGAP100F RhoGAP102A RhoGAPp190 Rlip Rnor\p190 rok scb Scer\GAL4 sqh Src64B T:Avic\GFP T:Hsap\MYC T:Zzzz\FLAG tum w
Insertions (8)
	P{GawB}ey^OK107 P{GawB}T80 P{UAS-Rho1.V14.E40L}9 P{UAS-Rho1.V14.F39V}13 P{UAS-Rho1.V14.F39V}15 P{UAS-Rho1.V14.F39V}40 P{UAS-RhoGAPp190.GAP-dsRNA}5.2 P{UAS-RhoGAPp190.GAP-dsRNA}14.1
Transcripts (1)
	Scer\GAL4^T80RA